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| Drug class description : | Aminoglycosides. |
| Generic Name : | Tobramycin |
| Drug description : | Solution in vials. |
| Presentation : | Injection, tobramycin (as sulphate) 20, 40 and 80 mg . |
| Indications : | Treatment of the following infections caused by susceptible micro-organisms: central nervous system infections (including meningitis, septicaemia and neonatal sepsis); gastrointestinal infections (including peritonitis, complicated and recurrent urinary tract infections); lower respiratory tract infections (including pneumonia, bronchopneumonia and acute bronchitis); skin, bone and soft tissue infections (including burns). Tobramycin is usually active against most strains of the following organisms: Pseudomonas aeruginosa; Proteus species (indole positive and indole negative), including Pr. mirabilis, Pr. rettgeri and Pr. vulgaris; Morganella morganii; vulgaris; Morganella morganii; Escherichia coli; Klebsiella- Enterobacter-Serratia species; Citrobacter species; Providencia species; Staphylococci including Staphylococcus aureus (coagulase-positive and coagulase-negative). |
| Adult Dosage : | 3 - 5 mg/kg daily in three or four divided doses by intramuscular injection or intravenous injection or infusion. |
| Child Dosage : | Neonates, up to 4 mg/kg daily in two equal doses; others, 6 - 7.5 mg/kg daily in three or four divided doses. |
| Contra Indications : | Pregnancy, lactation. |
| Special Precautions : | Renal impairment; control blood levels and dosage. |
| Interactions : | Other aminoglycosides, loop diuretics, neuromuscular blocking agents. |
| Adverse Reactions : | Anaphylaxis, ototoxicity, nephrotoxicity. Raised liver enzymes. |
| Manufacturer : | King |
| Drug Availability : | (POM) |
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