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| Drug class description : | Cephalosporins. |
| Generic Name : | Cefazolin [cephazolin] |
| Drug description : | Powder in rubber-stoppered vials. |
| Presentation : | Powder for injections, cefazolin (cephazolin)(as sodium salt) 500 mg , 1 g. |
| Indications : | Treatment of the following infections due to susceptible micro-organisms: respiratory tract infections; genito-urinary tract infections; skin and soft tissue infections; bone and joint infections; septicaemia; endocarditis; biliary tract infections. Prophylaxis of postoperative infection in patients undergoing contaminated or potentially contaminated surgical procedures associated with a high risk of infection, or where the occurrence of a postoperative infection could be especially serious. Cefazolin is active against the following organisms in vitro: Staphylococcus aureus (penicillin-sensitive and penicillin-resistant); Staphylococcus epidermidis; Group A beta-haemolytic Group A beta-haemolytic streptococci and other strains of streptococci (many strains of enterococci are resistant); Streptococcus pneumoniae; Escherichia coli; Klebsiella species; Proteus mirabilis; Haemophilus influenzae; Enterobacter aerogenes. |
| Adult Dosage : | 500 mg - 1 g by intramuscular or intravenous injection six to eight hourly. (UTI, 500 mg - 1 g 12 hourly.) |
| Child Dosage : | Under 1 month, not recommended; others, 25 - 50 mg/kg daily in three or four divided doses by intramuscular or intravenous injection. |
| Contra Indications : | Known allergy to cephalosporins. |
| Special Precautions : | Hypersensitivity to b-lactam antibiotics. In beta-haemolytic infections, continue therapy for at least ten days. Impaired renal function. |
| Interactions : | Loop diuretics, probenecid, aminoglycosides. |
| Adverse Reactions : | Pain at injection site, hypersensitivity reations. GI disturbances, candidiasis, convulsions, eosinophilia, neutropenia, leucopenia, thrombocythaemia, rise in liver enzymes and blood urea. Positive Coomb's test. |
| Manufacturer : | Lilly |
| Drug Availability : | (POM) |
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