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| Drug class description : | Fibrinolytics. |
| Generic Name : | Streptokinase |
| Drug description : | Powder in vials. |
| Presentation : | Infusion, streptokinase 250,000 units ; 750,000 units ; 1.5 million units . |
| Indications : | Deep vein thrombosis, pulmonary embolism, acute arterial thromboembolism, acute myocardial infarction, clotted haemodialysis shunts. |
| Adult Dosage : | Intravascular administration: initially 600,000 i.u. over 30 - 60 minutes, maintenance, 100, 000 i.u. hourly for 3 - 6 days. Acute M.I., 1 .5 million i.u. by intravenous infusion over 1 hour; see data sheet. Haemodialysis shunts: see data sheet. |
| Child Dosage : | Titrate initially; maintenance, 1300 - 1400 i.u./kg body-weight/ hour for 3 - 6 days. See data sheet. Not recommended in acute M.I. |
| Contra Indications : | Allergy to streptokinase, recent streptokinase therapy (5 days to 6 months previously), severe liver or kidney damage. Recent haemorrhage or CVA, fibrinolysis and uncontrolled bleeding disorders, haemorrhagic diathesis, severe hypertension, streptococcal infections, subacute bacterial endocarditis. Recent surgery, bleeding tendencies. Pregnancy. |
| Special Precautions : | Obtain haemostatic status of patient before starting therapy. Follow up with anticoagulant therapy; see data sheet. Haemorrhagic retinopathy. |
| Interactions : | Anticoagulants, drugs affecting platelet function. |
| Adverse Reactions : | Hypotension, arrhythmias. Febrile reactions, anaphylaxis (rare), polyneuropathy, uveitis. Haemorrhage. |
| Manufacturer : | Pharmacia & Upjohn |
| Drug Availability : | (POM) |
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