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| Drug class description : | Cardioselective b-blockers (beta- blockers) / thiazide diuretics (thiazides) / K+-sparing diuretics (potassium-sparing diuretics). |
| Generic Name : | Atenolol, hydrochlorothiazide, amiloride |
| Drug description : | Red and cream capsules marked with KALTEN and logo. |
| Presentation : | Capsules, atenolol 50mg, hydrochlorothiazide 25mg, amiloride hydrochloride 2.5mg. |
| Indications : | Hypertension. |
| Adult Dosage : | 1 daily. |
| Child Dosage : | Not recommended. |
| Contra Indications : | 2nd or 3rd degree AV block, sinus bradycardia, sick sinus syndrome, severe peripheral arterial disease, uncompensated cardiac failure, cardiogenic shock, hypotension, untreated phaechromocytoma. Anuria, severe or progressive renal failure. Known hypersensitivity to components. Metabolic acidosis. Hyperkalaemia (serum K+ greater than 5.5mmol/L). Diabetic nephropathy. Prinzmetal's angina. |
| Special Precautions : | Poor cardiac reserve should be controlled with digitalis and diuretics. History of bronchospasm (cardio-selective b- blockers usually have a lesser effect on airways resistance than the non-selective type but their use should also be avoided in patients with wheezing or obstructive airways disease unless there are compelling clinical reasons). Diabetes; metabolic acidosis. Asthenic symptoms. Cerebrovascular insufficiency. Renal or hepatic impairment, thyrotoxic crisis. General anaesthesia; consider withdrawal before elective surgery. Pregnancy, lactation. Withdraw gradually. Gout, diabetes, hyperlipidaemia. Monitor electrolyte levels; K+- sparing diuretics can cause hyperkalaemia in which case K+- supplements are contraindicated. |
| Interactions : | Clonidine withdrawal, verapamil, diltiazem, class I antiarrhythmics, class II calcium antagonists, cardiac depressant anaesthetics, hypoglycaemics, reserpine, other antihypertensives, ergot alkaloids, cimetidine, rifampicin, theophylline, warfarin, CNS depressants, sympathomimetics, indometacin (indomethacin). Lithium, NSAIDs, digitalis, allopurinol, |
| Adverse Reactions : | Cold extremities, sleep disturbances (particularly with the more lipophilic drugs), bradycardia, exertional tiredness, bronchospasm, heart failure, hypotension, GI upset. If unexplained dry eyes or skin rash occur withdraw gradually. Gout, photosensitivity, rash, blood dyscrasias, weakness. |
| Manufacturer : | AstraZeneca |
| Drug Availability : | (POM) |
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