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| Drug class description : | Non-cardioselective b-blockers (beta-blockers). |
| Generic Name : | Propranolol - angina |
| Drug description : | Inderal LA: 160 mg lavender/pink sustained-release capsule marked INDERAL LA. Half-Inderal LA: 80 mg lavender/ pink sustained-release capsule marked HALF-INDERAL LA. Inderal Tablets: pink f-c tablets marked with tablet name and strength. |
| Presentation : | Inderal LA: Propranolol hydrochloride 160mg . Half-Inderal LA: Propranolol hydrochloride 80mg . Inderal Tablets: Propranolol hydrochloride 10 mg , 40 mg , 80 mg . |
| Indications : | Inderal LA and Half-Inderal LA: Angina. Inderal Tablets: Angina. Fallot's Tetralogy. |
| Adult Dosage : | Inderal LA and Half-Inderal LA: 80 mg or 160 mg daily; maximum 240 mg daily. Inderal Tablets: Angina, initially 40 mg two or three times daily increasing as necessary at weekly intervals; usual dose 120 - 240mg daily. |
| Child Dosage : | Inderal LA and Half-Inderal LA: Not recommended. Inderal Tablets: Fallot's Tetralogy, up to 1 mg/kg body- weight three or four times daily, as required. |
| Contra Indications : | 2nd or 3rd degree AV block, sinus bradycardia, sick sinus syndrome, after prolonged fasting, severe peripheral arterial disease, uncompensated cardiac failure, cardiogenic shock, hypotension, untreated phaeochromocytoma. Generally contra-indicated in patients with obstructive airways disease or a history of bronchospasm. Known hypersensitivity. Prinzmetal's angina. Metabolic acidosis. |
| Special Precautions : | Poor cardiac reserve should be controlled with digitalis and diuretics. First degree AV block, portal hypertension. Diabetes; metabolic acidosis. Asthenic symptoms. Cerebrovascular insufficiency. Renal or hepatic impairment, thyrotoxicosis. General anaesthesia; consider withdrawal before elective surgery. Pregnancy, lactation. Withdraw gradually. |
| Interactions : | Clonidine withdrawal, verapamil, diltiazem, class I antiarrhythmics, class II calcium antagonists, cardiac depressant anaesthetics, hypoglycaemics, reserpine, other antihypertensives, ergot alkaloids, cimetidine, rifampicin, theophylline, warfarin, CNS depressants, sympathomimetics, indometacin (indomethacin), ibuprofen, chlorpromazine. Refer to Summary |
| Adverse Reactions : | Cold extremities, sleep disturbances, bradycardia, bronchospasm, heart failure deterioration, postural hypotension, GI upset, alopecia, precipitation of heart block, exacerbation of intermittent claudication, Raynaud's phenomenon, confusion, dizziness, mood changes, nightmares, psychoses and hallucinations, purpura, thrombocytopenia, dry eyes, psoriasiform skin reactions, exacerbation of psoriasis, skin rashes, paraesthesia, visual disturbances, fatigue and/or lassitude, increase in antinuclear antibodies. |
| Manufacturer : | AstraZeneca |
| Drug Availability : | (POM) |
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