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| Drug class description : | Potassium channel activators. |
| Generic Name : | Nicorandil |
| Drug description : | White scored tablets marked IK10 or IK20. |
| Presentation : | Tablets, nicorandil 10 mg , 20 mg . |
| Indications : | Prevention and treatment of angina. |
| Adult Dosage : | Initially 10 mg twice daily. Titrate according to response. Maintenance, 10 - 20 mg twice daily; maximum 30 mg twice daily. Patients susceptible to headache, initially 5 mg twice daily. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Cardiogenic shock, left ventricular failure with low filling pressures, hypotension. Patients who have demonstrated an idiosyncratic response or hypersensitivity to nicorandil. Concomitant use of Ikorel and sildenafil (Viagra) is contraindicated. Pregnancy, lactation. |
| Special Precautions : | Use of nicorandil should be avoided in patients with depleted blood volume, low systolic blood pressure, acute pulmonary oedema or acute myocardial infarction with acute left ventricular failure and low filling pressures. Used with care when prescribed with antihypertensive drugs. Alternative therapy should be considered if persistent aphtosis or severe mouth ulceration occurs. |
| Interactions : | Hypotensive agents, TCADs, |
| Adverse Reactions : | Headache, vasodilatation, nausea, vomiting, dizziness, feeling of weakness. Hypotension and/or tachycardia at high therapeutic doses. Rarely, myalgia and rash, persistent aphtosis or mouth ulcers. Very rarely, angioedema, hepatic function abnormalities. |
| Manufacturer : | Aventis |
| Drug Availability : | (POM) |
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