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| Drug class description : | Non-steroidal anti-inflammatory drugs (NSAIDs, prostaglandin synthetase inhibitors.) |
| Generic Name : | Indometacin (indomethacin) |
| Drug description : | Powder in vial. |
| Presentation : | Powder for injection, indometacin (as sodium trihydrate) 1mg. |
| Indications : | Patent ductus arteriosus in premature babies. |
| Adult Dosage : | Not applicable. |
| Child Dosage : | A course of three doses at 12- 24 hour intervals based on age of neonate and urinary output by intravenous infusion over 20-30 minutes; see Summary of Product Characteristics. |
| Contra Indications : | Untreated infection, intracranial or GI bleeding, thrombocytopenia, coagulation defects, necrotising enterocolitis, significant renal impairment, conditions where patency needs to be preserved. |
| Special Precautions : | Monitor renal function, plasma electrolytes and for signs of bleeding, discontinue if liver disease develops. Risk of renal failure is increased in babies failure is increased in babies with extracellular volume depletion, CHF, sepsis or hepatic dysfunction. May mask symptoms of infection. |
| Interactions : | Digitalis, frusemide (furosemide) , aminoglycosides. |
| Adverse Reactions : | GI upset, increased risk of bleeding, renal dysfunction, electrolyte imbalance, fluid retention, exacerbation of infection. |
| Manufacturer : | MSD |
| Drug Availability : | (POM) |
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