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| Drug class description : | Non-steroidal anti-inflammatory drugs (NSAIDs). |
| Generic Name : | Generic |
| Presentation : | Capsules, indometacin 25 mg , 50 mg . Available from Cox, Generics UK (50mg only), Hillcross, Ranbaxy, Regent. Capsules, indometacin 75mg sustained release. Available from Ashbourne (IndomaxR 75 SR), Cox (Pardelprin R MR), Generics UK, Hillcross (Rheumacin R LA), Lagap (IndolarR SR). Suppositories, indometacin 100 mg . Available from Cox, Hillcross, Norton. |
| Indications : | Rheumatoid arthritis, acute musculoskeletal disorders. Dysmenorrhoea. Acute gout. |
| Adult Dosage : | Rheumatoid arthritis, orally, 50- 200mg daily in divided doses;rectally, 100mg at night (or twice daily if required). Acute gout, orally, 150-200mg Acute gout, orally, 150-200mg daily in divided doses; rectally, 100mg at night (or twice daily if required). Dysmenorrhoea, up to 75mg daily. Note: Total daily dose (combined oral and rectal treatment) = 150- 200mg. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Active peptic ulcer, history of gastro-intestinal lesions. Aspirin/anti-inflammatory induced allergy. Recent proctitis or rectal bleeding (suppositories). Nasal polyps with angioneurotic oedema. Pregnancy, lactation. |
| Special Precautions : | Renal or hepatic impairment; monitor on long term therapy. CNS disorders. Predisposition to fluid retention. In chronic rheumatoid arthritis, examine eyes regularly, discontinue if changes seen. Can mask signs of infection. Coagulation defects; monitor. Diabetes. Elderly. Extracellular volume depletion, sepsis. Monitor blood and gastrointestinal tract. |
| Interactions : | Salicylates, other NSAIDs, anticoagulants, lithium, corticosteroids, diuretics, antihypertensives, probenecid, aminoglycosides, methotrexate, quinolones, cyclosporin, digoxin, phenylpropanolamine, nephrotoxic drugs. |
| Adverse Reactions : | Gastrointestinal bleeding or persistent headaches (discontinue if occur). Corneal deposits, retinal disturbances (perform periodic eye tests on long-term therapy). Gastrointestinal intolerance, dizziness, CNS effects, blood dyscrasias. |
| Drug Availability : | (POM) |
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