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| Drug class description : | Non-cardioselective b-blockers (beta-blockers) / thiazide diuretics (thiazides). |
| Generic Name : | Propranolol, bendrofluazide [bendroflumethiazide] |
| Drug description : | Pink/grey sustained-release capsules marked INDEREX. |
| Presentation : | Capsules, propranolol hydrochloride 160mg, bendrofluazide 5mg. |
| Indications : | Hypertension. |
| Adult Dosage : | 1 daily. |
| Child Dosage : | Not recommended. |
| Contra Indications : | 2nd or 3rd degree AV block, sinus bradycardia, sick sinus syndrome, after prolonged fasting, severe peripheral arterial disease, uncompensated cardiac failure, cardiogenic shock, hypotension, untreated phaechromocytoma. Non- cardioselective b-blockers are also generally contra-indicated in patients with obstructive airways disease or a history of bronchospasm. Anuria, severe or progressive renal failure. Known hypersensitivity to either component. Prinzmetal's angina. Metabolic acidosis. |
| Special Precautions : | Poor cardiac reserve should be controlled with digitalis and diuretics. Portal hypertension. Diabetes; metabolic acidosis. Asthenic symptoms. Cerebrovascular insufficiency. Renal or hepatic impairment, thyrotoxicosis. General anaesthesia; consider withdrawal before elective surgery. Pregnancy, lactation. Withdraw gradually. Gout, diabetes, hyperlipidaemia. Monitor electrolyte levels; thiazide diuretics can cause hypokalaemia so K +-supplements may be required. |
| Interactions : | Clonidine withdrawal, verapamil, diltiazem, class II antiarrhythmics, cardiac depressant anaesthetics, hypoglycaemics, reserpine, other antihypertensives, ergot alkaloids, cimetidine, rifampicin, theophylline, warfarin, CNS depressants, sympathomimetics, indometacin (indomethacin), ibuprofen. Lithium, NSAIDs, digitalis, allopurinol, amantadine. |
| Adverse Reactions : | Cold extremities, sleep disturbances, bradycardia, exertional tiredness, bronchospasm, heart failure deterioration, postural hypotension, GI upset, alopecia, exacerbation of intermittent claudication, Raynaud's phenomenon, confusion, dizziness, mood changes, nightmares, psychoses and hallucinations, purpura, thrombocytopenia, alopecia, dry eyes, psoriasiform skin reactions, exacerbation of psoriasis, skin rashes, paraesthesia, visual disturbances, gout, photosensitivity, rash, blood dyscrasias, weakness, fatigue and/or lassitude, increase in antinuclear antibodies. |
| Manufacturer : | AstraZeneca |
| Drug Availability : | (POM) |
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