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| Drug class description : | Oestrogens. |
| Generic Name : | Estriol [oestriol], estrone [oestrone], estradiol [oestradiol] |
| Drug description : | Pink scored tablets. |
| Presentation : | Tablets, estriol 0.27 mg, estrone 1.4 mg , estradiol 0.6 mg . |
| Indications : | HRT for menopausal symptoms. Prevention of post-menopausal osteoporosis. |
| Adult Dosage : | 1 - 2 daily taken continuously or cyclically. If uterus is intact, cyclically. If uterus is intact, also give a progestogen for 12 or 13 days of each 28 day cycle. |
| Child Dosage : | Not applicable. |
| Contra Indications : | Cancer of breast, genital tract or other oestrogen-dependent carcinoma, undiagnosed vaginal bleeding or endometriosis. Active thrombophlebitis or thromboembolic disorders. Severe cardiac, hepatic or renal disease. Dubin-Johnson or Rotor syndromes. Pregnancy, lactation. |
| Special Precautions : | History or increased risk of thromboembolic disorders. Mild chronic liver disease; monitor liver function every 8 to 12 weeks. Closely monitor patients with cholelithiasis, otosclerosis, migraine, multiple sclerosis, epilepsy, diabetes, hypertension, porphyria, uterine fibroids, tetany. Examine blood pressure, pelvic organs and breasts (particularly those with fibrocystic disease of the breast or a family history of breast cancer) before and regularly during treatment. If breakthrough bleeding is persistent, perform endometrial assessment, which may include biopsy. |
| Interactions : | Liver enzyme inducing drugs. |
| Adverse Reactions : | GI upset, nausea, vomiting, weight gain, breast tenderness and enlargement, breakthrough bleeding, headache, dizziness, impaired liver function, cholestatic jaundice, epistaxis, migraine, thromboembolic disorders, exacerbation of varicose veins, increased blood pressure, transient erythema, generalised pruritus. REASONS FOR IMMEDIATE DISCONTINUATION OF TREATMENT: Occurence of migraine-type headaches for the first time, frequent severe headaches, acute visual disturbances, signs of thrombophlebitis or thromboembolism, or any other possible prodromal symptoms of vascular occlusion. Rise in blood pressure. Jaundice. Pregnancy. major elective surgery and during immobilisation entailing risk of thrombosis. |
| Manufacturer : | Shire |
| Drug Availability : | (POM) |
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