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| Drug class description : | Nucleoside reverse transcriptase inhibitors (NRTIs). |
| Generic Name : | Zalcitabine |
| Drug description : | Beige or grey oval f-c tablets marked with name, strength and Roche. |
| Presentation : | Tablets, zalcitabine 0.375 mg, 0.75 mg. |
| Indications : | In combination with other antiretroviral agents in HIV infection. |
| Adult Dosage : | 0.75 mg every 8 hours. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Peripheral neuropathy. |
| Special Precautions : | Patients at risk of developing peripheral neuropathy or pancreatitis, or with low CD4 count; monitor haematology, biochemistry and serum amylase. Renal or hepatic impairment, history of alcohol abuse, heart failure. Pregnancy, lactation. |
| Interactions : | Drugs likely to cause peripheral neuropathy, didanosine, amphotericin, foscarnet, aminoglycosides, i.v. pentamidine. |
| Adverse Reactions : | Peripheral neuropathy, pancreatitis, GI disorders, rash, pruritus, sweats. Rarely, lactic acidosis in absence of hypoxaemia, severe hepatomegaly with steatosis, hepatic failure, oesophageal ulcers, anaphylaxis. |
| Manufacturer : | Roche |
| Drug Availability : | (POM) |
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