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| Drug class description : | Oestrogens. |
| Generic Name : | Estradiol [oestradiol] |
| Drug description : | Transdermal patches. |
| Presentation : | Patches, releasing estradiol 50, 75, 100 microgram per 24 hours. |
| Indications : | Relief of menopausal symptoms, prevention of postmenopausal bone prevention of postmenopausal bone loss. |
| Adult Dosage : | Apply patch to clean, non-hairy area of skin below the waist and replace with a new patch every 7 days using a different site. Start with 50 microgram patch, increase if necessary to max. 100 microgram patch after first few months. In women with a uterus, a progestogen should also be given for at least 10 days of each cycle. |
| Child Dosage : | Not applicable. |
| Contra Indications : | Cancer of breast, genital tract or other oestrogen-dependent carcinoma, undiagnosed vaginal bleeding or endometriosis. Active thrombophlebitis or thromboembolic disorders. Severe cardiac, hepatic or renal disease. Dubin-Johnson or Rotor syndromes. Pregnancy, lactation. |
| Special Precautions : | History or increased risk of thromboembolic disorders. Mild chronic liver disease; monitor liver function every 8 to 12 weeks. Closely monitor patients with cholelithiasis, otosclerosis, migraine, multiple sclerosis, epilepsy, diabetes, hypertension, porphyria, uterine fibroids, tetany. Examine blood pressure, pelvic organs and breasts (particularly those with fibrocystic disease of the breast or a family history of breast cancer) before and regularly during treatment. If breakthrough bleeding is persistent, perform endometrial assessment, which may include biopsy. |
| Interactions : | Liver enzyme inducing drugs. |
| Adverse Reactions : | GI upset, nausea, vomiting, weight gain, breast tenderness and enlargement, breakthrough bleeding, headache, dizziness, impaired liver function, cholestatic jaundice, epistaxis, migraine, thromboembolic disorders, exacerbation of varicose veins, increased blood pressure, transient erythema, REASONS FOR IMMEDIATE DISCONTINUATION OF TREATMENT: Occurence of migraine-type headaches for the first time, frequent severe headaches, acute visual disturbances, signs of thrombophlebitis or thromboembolism, or any other possible prodromal symptoms of vascular occlusion. Rise in blood pressure. Jaundice. Pregnancy. Discontinue six weeks before major elective surgery and during immobilisation entailing risk of thrombosis. |
| Manufacturer : | Merck |
| Drug Availability : | (POM) |
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