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| Drug class description : | Oestrogens. |
| Generic Name : | Estradiol [oestradiol] |
| Drug description : | Fematrix 40: transdermal matrix patch. Fematrix 80: transdermal matrix patch. |
| Presentation : | Fematrix 40: Estradiol 40 microgram per 24 hours. Fematrix 80: Estradiol 80 microgram per 24 hours. |
| Indications : | Fematrix 40: HRT for menopausal Fematrix 40: HRT for menopausal oestrogen deficiency. Fematrix 80: HRT for menopausal oestrogen deficiency. Prevention of osteoporosis. |
| Adult Dosage : | Initiate therapy with Fematrix 40 in women who have menopausal symptoms, or who have been oestrogen-deficient for a long time, or who are likely to be intolerant of higher doses of oestrogen. Increase to Fematrix 80 if necessary, reduce to lowest effective dose for maintenance. Prevention of osteoporosis, use Fematrix 80. Apply patch to clean, non-hairy area of skin below the waist and replace with a new patch every 3 - 4 days using a different site. In women with a uterus, a progestogen should also be given for last 12 - 14 days of each cycle. |
| Child Dosage : | Not applicable. |
| Contra Indications : | Cancer of breast, genital tract or other oestrogen-dependent carcinoma, undiagnosed vaginal bleeding or endometriosis. Active deep vein thrombosis, thromboembolic disorders or a history of confirmed venous thromboembolism. Severe cardiac, renal disease, acute or chronic liver disease. Dubin-Johnson or Rotor syndromes. Pregnancy, lactation. |
| Special Precautions : | The patient should undergo thorough examination before commencing therapy and at regular intervals thereafter. Unopposed estradiol therapy should not be used in non-hysterectomised women because of the increased risk of endometrial hyperplasia or carcinoma. An increased risk of being diagnosed with breast cancer has been reported with HRT. Monitor patients with otosclerosis, multiple sclerosis, hypertension, epilepsy, systemic lupus erythematosus, cholelithiasis, porphyria, melanoma, migraine, thyrotoxicosis, surgically confirmed gall bladder disease, uterine fibroids or endometriosis. HRT is associated with an increased risk of venous thromboembolism (VTE). Oestrogens may cause fluid retention: monitor patients with cardiac or renal dysfunction. Women of childbearing potential should be advised to use non-hormonal contraceptive methods. |
| Interactions : | Liver enzyme inducing drugs. |
| Adverse Reactions : | Breast tenderness, abdominal cramps and bloating, oedema, nausea, weight changes, dysmenorrhoea, leg cramps, visual disturbances, breakthrough bleeding, headache, dizziness, migraine, transient erythema, generalised pruritus. REASONS FOR IMMEDIATE DISCONTINUATION OF TREATMENT: Occurence of migraine-type headaches for the first time, frequent severe headaches, acute visual disturbances, signs of thrombophlebitis or thromboembolism, or any other possible prodromal symptoms of vascular occlusion. Rise in blood pressure. Jaundice. Pregnancy. Discontinue four weeks before major elective surgery and during immobilisation entailing risk of thrombosis. |
| Manufacturer : | Solvay |
| Drug Availability : | (POM) |
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