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| Drug class description : | Sulphonamides / diaminopyrimidines (antimalarials). |
| Generic Name : | Sulfadoxine, pyrimethamine |
| Drug description : | White quarter-scored tablets marked ROCHE with hexagon. |
| Presentation : | Tablets, sulfadoxine 500mg, pyrimethamine 25mg. |
| Indications : | Indicated for the treatment of Plasmodium falciparum malaria and in restricted circumstances can be used for the prophylaxis can be used for the prophylaxis of Plasmodium falciparum malaria. |
| Adult Dosage : | Treatment, over 14 years, 2 - 3 tablets as a single dose. Prophylaxis, over 14 years, 1 weekly. Refer to Summary of Product Characteristics. |
| Child Dosage : | Treatment, given as a single dose: under 2 years (5-10kg), half a tablet; 2 - 5 years (>10- 20kg), one tablet; 5 - 10 years (>20-30kg), one and a half tablets; 10 - 14 years (>30-45kg) , two tablets. Prophylaxis, given once every seven days: under 2 years (5- 10kg), quarter of a tablet; 2 - 10 years (>10-30kg), half a tablet; 10 - 14 years (>30-45kg), three quarters of a tablet. Refer to Summary of Product Characteristics. |
| Contra Indications : | Sulphonamide sensitivity. Severe liver or kidney dysfunction. Blood dyscrasias. Neonates, pregnancy, lactation. |
| Special Precautions : | Perform regular blood counts during long-term prophylaxis. Avoid excess sun. |
| Interactions : | Folate inhibitors. |
| Adverse Reactions : | Skin rash, pharyngitis or pruritus (discontinue immediately). GI distress, blood dyscrasias. Rarely erythema multiforme, Stevens-Johnson syndrome, Lyell's syndrome. |
| Manufacturer : | Roche |
| Drug Availability : | (POM) |
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