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| Drug class description : | H2 -antagonists (H2 -receptor antagonists / H 2 -blockers). |
| Generic Name : | Generic |
| Drug description : | Tablets. |
| Presentation : | Tablets, famotidine 20mg , 40mg . Available from APS, Hillcross, Lagap, Norton. |
| Indications : | Duodenal and benign gastric ulcers. Prevention of relapse of duodenal ulceration. Zollinger- Ellison syndrome. Prevention and treatment of gastro-oesophageal reflux disease. |
| Adult Dosage : | Benign gastric and duodenal ulcer, 40 mg at night for four to eight weeks. Prophylaxis of duodenal ulcer relapse, 20 mg at night. Zollinger-Ellison syndrome, initially, 20 mg every six hours, adjust as necessary; maximum 800 mg daily. Gastro-oesophageal reflux disease, 20 mg twice daily for six to 12 weeks; if also erosion six to 12 weeks; if also erosion or ulceration, 40 mg twice daily for six to 12 weeks. Prophylaxis 20 mg twice daily. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Hypersensitivity to any component. |
| Special Precautions : | Impaired renal function, gastric carcinoma. Pregnancy, lactation. |
| Adverse Reactions : | Headache, dizziness, CNS disturbances, dry mouth, constipation, diarrhoea, nausea, rash, GI discomfort, anorexia, fatigue, arthralgia, muscle cramps, liver enzyme abnormalities. Rarely, reversible gynaecomastia, toxic epidermal necrolysis. |
| Drug Availability : | (POM) |
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