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| Drug class description : | Non-steroidal anti-inflammatory drugs (NSAIDs). |
| Generic Name : | Diclofenac sodium |
| Drug description : | Suppositories. Solution for injection. |
| Presentation : | Suppositories, diclofenac sodium 100mg. Injection, diclofenac 75mg/3mL. |
| Indications : | Econac Suppositories: Relief of all grades of pain and inflammation in a wide range of conditions, including: arthritic conditions such as rheumatoid arthritis, osteo-arthritis, ankylosing spondylitis, acute gout; acute musculoskeletal disorders such as peri-arthritis (eg, frozen shoulder), tendinitis, tenosynovitis, bursitis; other painful conditions resulting from trauma, including fracture, low back pain, sprains, strains, dislocations, orthopaedic, dental and other minor surgery. Econac Injection: Acute forms of pain, including renal colic; exacerbations of osteo- and rheumatoid arthritis; acute back rheumatoid arthritis; acute back pain; acute gout; acute trauma and fractures; postoperative pain. |
| Adult Dosage : | Econac Suppositories: One 100mg suppository may be given as a once daily treatment, usually at night. Where necessary, therapy may be combined with tablets up to a total maximum dose of 150mg diclofenac per day. Econac Injection: one ampoule once (or in severe cases twice) daily intramuscularly by deep intragluteal injection into the upper outer quadrant. If two injections daily are required, use the alternate buttock for the second injection. Econac injection should not be given for more than two days; if necessary, treatment can be continued with tablets or suppositories. Renal colic: one ampoule intramuscularly, repeated after 30 minutes if necessary. |
| Child Dosage : | Not suitable. |
| Elderly Dosage : | Use lowest effective dose. |
| Contra Indications : | Active or suspected peptic ulcer or gastrointestinal bleeding. Previous sensitivity to diclofenac. Patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory drugs. Suppositories: In ulcerative or acute inflammatory conditions of the anus, rectum (proctitis) and sigmoid colon. Injection: Hypersensitivity to the excipients mannitol, propylene glycol, benzyl alcohol, sodium metabisulphite, sodium hydroxide. |
| Special Precautions : | Asthma, chronic obstructive diseases of the respiratory tract, allergic rhinitis or swelling of the nasal mucosa. Symptoms or history suggestive of gastrointestinal ulceration. Ulcerative colitis, Crohn's disease, bleeding diathesis or haematological abnormalities. Elderly. Hepatic, renal or Hypersensitivity reactions may occur. Pregnancy and lactation. |
| Interactions : | Lithium, digoxin, anticoagulants, oral hypoglycaemics, cyclosporin, methotrexate, quinolone antibiotics. Other NSAIDs, steroids, potassium-sparing diuretics. |
| Adverse Reactions : | Gastrointestinal effects including nausea, vomiting, diarrhoea and minor GI blood loss. Occasionally, dyspepsia, flatulence, intestinal cramps, anorexia, peptic or intestinal ulcer. Isolated cases of aphthous stomatitis, glossitis, oesophageal lesions, lower abdominal pain, constipation. CNS effects including headache, excititation, irritability, insomnia, tiredness, confusion and giddiness. Occasionally, hypersensitivity reactions (rarely, Stevens-Johnson syndrome). Acute renal insufficiency (haematuria, proteinuria) or renal damage (interstitial nephritis, nephrotic syndrome or necrosis of renal papillae). Elevation of liver enzymes. Pancreatitis. Haematological effects including thrombocytopenia, agranulocytosis, haemolytic and aplastic anaemia. Peripheral oedema. Suppositories: local reactions including itching, burning and increased bowel movements. Injection: rarely, injection site disorders, eg, local pain and induration; in isolated cases, abscesses and local necrosis. |
| Manufacturer : | Goldshield |
| Drug Availability : | (POM) |
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