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| Drug class description : | Topoisomerase 1 inhibitors. |
| Generic Name : | Irinotecan |
| Drug description : | Solution in vials. |
| Presentation : | Solution for infusion, irinotecan hydrochloride trihydrate 20 mg / mL. |
| Indications : | Campto is indicated for the treatment of patients with advanced colorectal cancer: _in combination with 5- fluorouracil and folinic acid in patients without prior chemotherapy for advanced disease _as a single agent in patients who have failed an established 5- fluorouracil containing treatment regimen |
| Adult Dosage : | 350 mg/m2 by intravenous infusion over 30 - 90 minutes every 3 weeks. If patient develops severe neutropenia or severe diarrhoea reduce dose to 300 mg/ m2 and then 250 mg/m 2 in subsequent cycles. Continue treatment until disease progression or unacceptable toxicity. |
| Child Dosage : | Not recommended. Not recommended. |
| Contra Indications : | Chronic inflammatory bowel disease, bowel obstruction, hepatic impairment (bilirubin >1.5 times normal), renal impairment, severe myelosuppression, WHO performance status >2. Pregnancy, lactation. |
| Special Precautions : | Refer to Summary of Product Characteristics. |
| Adverse Reactions : | Delayed diarrhoea; warn patient of risk and start high dose loperamide immediately. Neutropenia; monitor neutrophil count, instruct patient to report fever. Anaemia, thrombocytopenia. Liver impairment; perform liver function tests. Nausea, vomiting, acute cholinergic syndrome, asthenia, alopecia, dyspnoea, cramps, paraesthesia. |
| Manufacturer : | Aventis |
| Drug Availability : | (POM) |
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