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| Drug class description : | Muscle relaxants (GABA derivatives). |
| Generic Name : | Generic Dose should be increased gradually to avoid sedation and hypotonia. |
| Drug description : | Tablets. |
| Presentation : | Tablets, baclofen 10 mg . Available from APS, Ashbourne (BaclospasR ), Berk (BalgifenR ), Co-Pharma, Cox, Generics UK, Hillcross, Lagap, Norton, Sovereign. |
| Indications : | Voluntary muscle spasticity due to cerebrovascular accidents, cerebral palsy, meningitis, multiple sclerosis, spinal lesions, head injury. For injection see Lioresal Intrathecal: Severe chronic spasticity associated with spinal injury or multiple sclerosis in patients intolerant or unresponsive to oral therapy. |
| Adult Dosage : | Initially, 5 mg three times daily, increasing as required by 5 mg three times daily at three day intervals; maximum 100 mg daily. Intrathecal injection requires test dose, titration steps and maintenance dose calculations. See Data Sheet. |
| Contra Indications : | Peptic ulceration. |
| Special Precautions : | Epilepsy, psychotic or convusional states, cerebrovascular accident., sphincter hypertonia, autonomic dysreflexia, history of peptic ulcer, respiratory, hepatic or renal impairment. Elderly. Pregnancy, lactation. Withdraw drug gradually over at least 1 - 2 weeks. Perform tests in liver disease or diabetes. For intrathecal injection: pre- operative assessment mandatory, abnormal CSF flow. |
| Interactions : | Antihypertensives, lithium, fentanyl, morphine, tricyclic antidepressants, ibuprofen, levodopa, carbidopa, alcohol, CNS depressants. |
| Adverse Reactions : | Nausea, sedation, dry mouth, hypotension, respiratory or cardiovascular depression, dysuria, frequency of micturition. Rarely visual disturbances, rash, deterioration in liver function tests, neurological and psychiatric symptoms. |
| Drug Availability : | (POM) |
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