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| Drug class description : | Xanthines (bronchodilators). |
| Generic Name : | Generic Aminophylline is a theophylline compound in combination with ethylenediamine. Theophylline has a narrow therapeutic window, to avoid toxicity and achieve optimum response a plasma theophylline level of 10 - 20mg/litre or 55-110 micromol/litre sho |
| Drug description : | Tablets/ampoules. |
| Presentation : | Tablets, aminophylline 100 mg . Available from Norton, Regent. Tablets, SR, aminophylline 225mg . Available from Ashbourne (Amnivent 225-SRR ), Norton (Norphyllin R ). Injection, aminophylline 25 mg / mL (POM). Available from Phoenix. |
| Indications : | Bronchospasm associated with asthma, COPD and chronic bronchitis. |
| Adult Dosage : | Orally, 100-300 mg, three to four Orally, 100-300 mg, three to four times daily, after food. Deteriorating acute severe asthma not previously treated with theophylline, by slow intravenous injection over 20 minutes, 250 - 500 mg (5 mg/kg), then as for acute severe asthma. Acute severe asthma, by intravenous infusion, 500 micrograms/kg/hour, adjusted according to plasma-theophylline concentration. Note: Patients taking oral theophylline or aminophylline should not normally receive intravenous aminophylline unless plasma-theophylline concentration is available to guide dosage. |
| Child Dosage : | Deteriorating acute severe asthma not previously treated with theophylline, 5 mg/kg, then as for acute severe asthma. Acute severe asthma, six months to nine years, 1 mg/kg/hour; 10- 16 years, 800 micrograms/kg/hour, adjusted according to plasma- theophylline concentration. |
| Contra Indications : | Sensitivity to theophylline or ethylene diamine. Acute porphyria. Concomitant administration with ephedrine in children. |
| Special Precautions : | Cardiac, liver or thyroid disease. Peptic ulceration. Pregnancy, lactation. |
| Interactions : | Cimetidine, nizatidine. Antibiotics (including ciprofloxacin, norfloxacin, clarithromycin, erythromycin, troleandomycin), isoniazid, fluconazole, viloxazine, combined oral contraceptives, carbimazole, thiabendazole, mexiletine, propafenone, calcium channel blockers (diltiazem, verapamil, possibly others), allopurinol, 2 oxpentifylline, other xanthines, disulfiram, interferon alfa, influenza vaccine, anticonvulants including carbamazepine, phenytoin, phenobarbitone and primidone, rifampicin, ritonavir, aminoglutethimide, sulfinpyrazone. b agonists, corticosteroids and diuretics, b- adrenocorticoids, glucocorticoids and mineralocorticoids, lithium, halothane. Fluvoxamine. |
| Adverse Reactions : | Nausea, gastric irritation, headache, CNS stimulation. |
| Drug Availability : | (POM) |
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