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| Drug class description : | Antifungals (polyene antibiotics) . |
| Generic Name : | Amphotericin B lipid complex |
| Drug description : | Sterile, pyrogen-free suspension in vial to be diluted for intravenous infusion only. 10mL vials (50mg, 50,000IU) or 20mL vials (100mg, 100,000 units). |
| Presentation : | Injection, amphotericin B lipid complex (ABLC) 5mg per mL. |
| Indications : | Treatment of severe invasive candidiasis. Second line therapy for the treatment of severe systemic fungal infections in patients who have not responded to conventional amphotericin B or other systemic antifungal agents, in those who have renal impairment or other contraindications to conventional amphotericin B, or in patients who have developed amphotericin B nephrotoxicity. Indicated as second line treatment for invasive aspergillosis, cryptococcal meningitis and disseminated cryptococcosis in HIV patients, fusariosis, coccidiomycosis, zygomycosis and coccidiomycosis, zygomycosis and blastomycosis. |
| Adult Dosage : | Refer to Summary of Product Characteristics. |
| Contra Indications : | Known hypersensitivity to any of constituents, unless in the opinion of the physician, the advantages of using Abelcet outweigh the risks of hypersensitivity. |
| Special Precautions : | Renal disease. Liver disease. Pregnancy and lactation. |
| Interactions : | Nephrotoxic drugs. Zidovudine, cyclosporin. Conventional amphotericin B as been reported to interact with antineoplastic agents, corticosteroids and corticotropin (corticotrophin, ACTH), digitalis glycosides and skeletal muscle relaxants. |
| Adverse Reactions : | Most commonly, chills, fever, nausea and vomiting. Allergic reactions including anaphylaxis, bronchospasm, dyspnoea and hypotension have also been reported. |
| Manufacturer : | The Liposome Co |
| Drug Availability : | (POM) |
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