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| Drug class description : | Low molecular weight heparins (LMWHs, anticoagulants). |
| Generic Name : | Certoparin |
| Drug description : | Solution in pre-filled syringes. |
| Presentation : | Injection, certoparin 3000 i.u. anti-Factor Xa activity. |
| Indications : | Prophylaxis of peri- and post- operative venous thromboembolism. |
| Adult Dosage : | 3000 i.u. daily by subcutaneous injection into the peritoneal fold 1 - 2 hours prior to surgery. Repeat once daily for 7 to 10 days or until mobile. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Major bleeding disorders, bleeding ulcers of the stomach or intestine, severe hypertension (>200/120mmHg), hypersensitivity to heparin, subacute bacterial endocarditis, severe renal and/or hepatic dysfunction. |
| Special Precautions : | Must not be administered intramuscularly. Monitor platelet counts. May cause hyperkalaemia, particularly in diabetes mellitus, chronic renal failure, mellitus, chronic renal failure, pre-existing metabolic acidosis, patients with raised plasma potassium or taking potassium- sparing drugs; measure plasma potassium before starting therapy, and monitor regularly thereafter, especially if treatment prolonged beyond 7 days. Spinal or epidural anaesthesia - risk of spinal haematomas and paralysis; observe patients carefully. Pregnancy and lactation. |
| Interactions : | NSAIDs, oral anticoagulants, dipyridamole, dextrans, etacrynic acid (ethacrynic acid), cytostatic agents, antihistamines, digitalis, tetracyclines, ascorbic acid. |
| Adverse Reactions : | Minor bleeding at injection site, thrombocytopenia, hypersensitivity reactions, raised liver enzymes, osteoporosis. Rarely, clinically significant hyperkalaemia. Very rarely, spinal haematomas in patients undergoing spinal or epidural anaesthesia. |
| Manufacturer : | Grifols |
| Drug Availability : | (POM) |
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