Want to submit or suggest content for the MiMedia Clinical Library?
Contact us here
EPG Online is not responsible for external content
Please register to access disease diagnosis, patient management, physician tools.
By viewing the content of this web page you are both confirming your status as a healthcare professional and agreeing to our terms of use.
| Drug class description : | Fibrinolytics. |
| Generic Name : | Alteplase |
| Drug description : | Powder in vial plus diluent. |
| Presentation : | Powder for injection, alteplase 10 mg , 20 mg , 50 mg . |
| Indications : | Acute myocardial infarction; acute pulmonary embolism. |
| Adult Dosage : | Total dose of 100 mg intravenously over three hours. MI: administer over 90 minutes if within 6 hours of symptom onset, over 3 hours if 6 - 12 hours. PE: administer over 2 hours. See Summary of Product Characteristics. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Situations where there is a high risk of haemorrhage such as: bleeding diathesis, within 10 bleeding diathesis, within 10 days of haemorrhage or surgery, active peptic ulceration, acute pancreatitis, bacterial endocarditis, severe liver disease; history of stroke or CNS damage; severe controlled hypertension. |
| Special Precautions : | Situations where risk of bleeding is increased. Pregnancy. Elderly. Actilyse should be given only by physicians experienced in the use of thrombolytics and with the facilities to monitor it. |
| Interactions : | Anticoagulants. |
| Adverse Reactions : | Bleeding is the most frequent adverse reaction. This may be superficial bleeding from punctures or damaged blood vessels, or internal bleeding into the urogenital tract, retroperitoneum or CNS or bleeding of parenchymatous organs. Intracranial haemorrhage. Cholesterol crystal embolisation or thrombotic embolisation rarely. Arrhythmias associated with reperfusion may occur. Nausea, vomiting, hypotension and fever may occur rarely. |
| Manufacturer : | Boehringer Ingelheim |
| Drug Availability : | (POM) |
Only registered users have access to the full EPG Online Knowledge Base including drug search tools, interactive disease Knowledge Centres via the EPG Knowledge Library - with clinical and evidence based physician and research tools, MiMedia (build your own clinical media collection with everything from key opinion leader essays to mode of action videos and other multi-media content), the EPG Survey panel, health news updates and much much more.
Already Registered?
Please log-in now using our member login box.
Not a member?
Don't worry, registration is quick and FREE! We welcome all Healthcare professionals, doctors, nurses and medical students.
Register today to have full access to a wealth of drug data, educational and evidence based interactive guides across all major therapeutic areas, disease management, and clinical tools.
As a practicing Healthcare professional, you can also opt-in to join our market research panel – www.epgsurvey.com – and get paid for sharing your expert clinical opinions!
REGISTER today it only takes a minute! and it's FREE
Having problems?
Use our forgotten password facility or email us at: contact@epgonline.org