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Medicine information : ARYTHMOL
| Drug class description : | Class I antiarrhythmics (anti- arrhythmics). |
| Generic Name : | Propafenone |
| Drug description : | 150 mg white f-c tablet; 300 mg white scored f-c tablet. |
| Presentation : | Tablets, propafenone hydrochloride 150mg , 300mg . |
| Indications : | Prophylaxis and treatment of ventricular arrhythmias. Prophylaxis and treatment of and paroxysmal supraventricular tachyarrhythmias when standard therapy has failed or is contraindicated. |
| Adult Dosage : | Initially 150 mg three times daily, increase at minimum 3 day intervals to maintenance dose of 300 mg twice daily; maximum 300 mg three times daily. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Uncontrolled congestive heart failure, cardiogenic shock (except arrhythmia induced), severe bradycardia, uncontrolled electrolyte disturbances, severe obstructive pulmonary disease, marked hypotension, myasthenia gravis, pregnancy, lactation. Unless adequately paced: sinus node dysfunction, atrial conduction defects, second degree or greater AV, bundle branch or distal block. |
| Special Precautions : | Therapy should be initiated under hospital supervision. Asthma, hepatic and renal impairment, cardiac failure, structural heart disease. Elderly, pacemaker patients. |
| Interactions : | Other class I antiarrhythmics or warfarin, cimetidine, propranolol, metoprolol, rifampicin, tricyclic and related anti-depressants, neuroleptics, cyclosporin, theophylline. |
| Adverse Reactions : | Dizziness, nausea, vomiting, bitter taste, constipation, diarrhoea, headache, fatigue. Allergic skin reactions, bradycardia, SA, AV or intraventricular blocks may occur. Proarrhythmic effects. |
| Manufacturer : | Knoll |
| Drug Availability : | (POM) |
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