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Medicine information : AXID
| Drug class description : | H2 -antagonists (H2 -receptor antagonists / H 2 -blockers). |
| Generic Name : | Nizatidine |
| Drug description : | Axid Capsules: 150mg pale/dark yellow capsule coded 'Lilly 3144'; 300 mg pale yellow/brown capsule coded 'Lilly 3145'. Axid Injection: ampoules. |
| Presentation : | Axid Capsules: Nizatidine 150mg , 300mg . Axid Injection: Nizatidine 25mg/ mL . |
| Indications : | Capsules: For the treatment of the following diseases where reduction of gastric acid is indicated: duodenal and benign gastric ulcers; prevention of duodenal or benign gastric ulcer recurrence; gastro-oesophageal reflux disease (including erosions, ulcerations and associated heartburn); gastric and/or duodenal ulcer associated with concomitant use of non- steroidal anti-inflammatory drugs. Injection: In hospitalised patients as an alternative to the oral dosage form, for short-term use in peptic ulcer patients until oral medication is indicated. |
| Adult Dosage : | Axid: Benign gastric and duodenal ulcers (including those associated with NSAIDs - treatment with NSAIDs may continue during treatment): 300 mg in evening for four or, if necessary, eight weeks. Alternatively, 150 mg morning and evening. Prophylaxis, 150 mg in the evening. Gastro-oesophageal reflux disease: 150 - 300 mg twice daily for up to 12 weeks. Dilute before administration. Continuous intravenous infusion: dilute 300mg (12mL) in 150mL of compatible intravenous solution and infuse at a rate to achieve 10mg per hour. Intermittent intravenous infusion: dilute 100mg (4mL) in 50mL of compatible intravenous solution and infuse over 15 minutes three times daily. Total daily dose should not exceed 480mg. |
| Child Dosage : | Not recommended. |
| Contra Indications : | Known hypersensitivity to H - receptor antagonists. 2 |
| Special Precautions : | Impaired renal or hepatic function. Pregnancy, lactation. Symptomatic response to nizatidine does not preclude the presence of gastric malignancy. |
| Interactions : | Salicylates. |
| Adverse Reactions : | Sweating, urticaria, somnolence, raised liver enzymes, hepatitis, jaundice. Rarely, hypersensitivity reactions, serum sickness and anaphylaxis. Injection: pain and minor bruising at injection site. Rarely, tachycardia, bradycardia, postural hypotension and syncope after rapid intravenous injection. |
| Manufacturer : | Lilly |
| Drug Availability : | (POM) |
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