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Medicine information : APROVEL
| Drug class description : | Angiotensin II antagonists (angiotensin II receptor antagonists) |
| Generic Name : | Irbesartan |
| Drug description : | White to off-white oval tablets marked with heart symbol and 2771, 2772 or 2773. |
| Presentation : | Tablets, irbesartan 75 mg , 150 mg , 300 mg . |
| Indications : | Essential hypertension. |
| Adult Dosage : | Initially 150 mg once daily. Increase if necessary to 300 mg once daily or add other antihypertensive agents. |
| Child Dosage : | Not recommended. |
| Elderly Dosage : | Over 75 years, consider starting dose of 75 mg once daily then titrate according to response. |
| Contra Indications : | Pregnancy, lactation. Hypersensitivity to any component of the product. |
| Special Precautions : | Correct volume and/or salt depletion before starting therapy. Renovascular hypertension. Renal impairment and kidney transplantation. Hyperkalaemia - adequate monitoring of serum potassium in Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy. Primary aldosteronism. Heart failure; monitor serum potassium and creatinine levels. |
| Interactions : | K+-sparing diuretics, K+ supplements, lithium. |
| Adverse Reactions : | Headache, musculoskeletal pain, flushing. Rarely during postmarketing surveillance, hypersensitivity reactions (rash, urticaria, angioedema). Very rarely, asthenia, diarrhoea, dizziness, dyspepsia, hyperkalaemia, myalgia, nausea and tachycardia. |
| Manufacturer : | Bristol-Myers Squibb/Sanofi- Synthelabo |
| Drug Availability : | (POM) |
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