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Anti-Infectives Knowledge Network

Anti-Infectives Knowledge Network

Bringing together resources from a number of major anti-infective congresses throughout 2012 and 2013, including ISICEM, EBMT, ECCMID, EHA, ESOT and TIMM; the Anti-infectives Knowledge Network shares the experience of a number of thought leaders.

Key transplantation reports and presentations from our 2013 coverage include:

Medical Videos

Heart Transplantation - The Reasons for Transplantation and the Success Rates
Heart Transplantation - The Reasons for Transplantation and the Success Rates
An Overview of Blood Transfusions
An Overview of Blood Transfusions
Corneal Transplant - The Diseases, Procedures and Success Rates
Corneal Transplant - The Diseases, Procedures and Success Rates
Lung Transplants - The Benefits and Limitations
Lung Transplants - The Benefits and Limitations

Recent Drug Updates

Clinical Guidelines

Management of cytomegalovirus infection in haemopoietic stem cell transplantation

May 2013

These evidence-based guidelines expand and adapt previous guidance (Tomblyn et al, 2009; Andrews et..

... al, 2011). While specifically focusing on allogeneic haemopoietic stem cell transplantation (HSCT), they are relevant to other areas of haematological oncology where there is an increased risk of cytomegalovirus (CMV) infection, such as haematological cancers where intense anti-T-cell therapy has been deployed (O’Brien et al, 2006).

ESCMID guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT)

Dec 2012

Fungal diseases still play a major role in morbidity and mortality in patients with haematological..

... malignancies, including those undergoing haematopoietic stem cell transplantation. Although Aspergillus and other filamentous fungal diseases remain a major concern, Candida infections are still a major cause of mortality. This part of the ESCMID guidelines focuses on this patient population and reviews pertaining to prophylaxis, empirical/pre-emptive and targeted therapy of Candida diseases. AntiCandida prophylaxis is only recommended for patients receiving allogeneic stem cell transplantation.

Clinical Trials

Pilot Feasibility Study of Combined Kidney and Hematopoietic Stem Cell Transplantation to Cure End-stage Renal Disease


This pilot study of combined kidney and hematopoietic stem cell transplantation attempts to establish a protocol to induce immunological tolerance as a new strategy to prevent renal graft rejection. If successful, this strategy would restore renal function, while avoiding the risks associated with long-term standard..

... anti-rejection therapy, and would represent the first option to cure end-stage renal disease.

Chronic Transplant Glomerulopathy and Regulation of Expression of Ephrin B1 (GARRE)


The principal purpose is the study of the regulation of the expression of ephrin-B1 by immunofluorescence in kidney biopsies of patients with Chronic transplant glomerulopathy (CTG) compared to biopsies prior to the CTG, in same patients. Level of fluorescence in CTG biopsy will be the experimental reference..

... value.

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