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Anti-Infectives Knowledge Network

Anti-Infectives Knowledge Network

Bringing together resources from a number of major anti-infective congresses throughout 2012 and 2013, including ISICEM, EBMT, ECCMID, EHA, ESOT and TIMM; the Anti-infectives Knowledge Network shares the experience of a number of thought leaders.

Key transplantation reports and presentations from our 2013 coverage include:

Medical Videos

Corneal Transplant - The Diseases, Procedures and Success Rates
Corneal Transplant - The Diseases, Procedures and Success Rates
An Overview of Blood Transfusions
An Overview of Blood Transfusions
Heart Transplantation - The Reasons for Transplantation and the Success Rates
Heart Transplantation - The Reasons for Transplantation and the Success Rates
Lung Transplants - The Benefits and Limitations
Lung Transplants - The Benefits and Limitations

Recent Drug Updates

Medical Journal Abstracts on Transplantation

Living vs. Deceased Donor Liver Transplantation Provides Comparable Recovery of Renal Function in Patients With Hepatorenal Syndrome: A Matched Case–Control Study

Thu 02 Oct 2014 -  American Journal of Transplantation

Outcomes of living versus deceased donor liver transplantation in patients with chronic liver disease and hepatorenal syndrome HRS was compared using a matched pair study design Thirty patients ...

Analysis of factors affecting immune recovery and initial response to tetanus after DTaP vaccination in pediatric allogeneic HSCT patients

Sun 21 Sep 2014 -  Pediatric Transplantation

Transfer of donor immunity after alloHSCT is limited requiring revaccination after HSCT The CDC 2009 guidelines introduced earlier vaccination postHSCT with a uniform vaccination strategy This ...

Clinical Guidelines

Management of cytomegalovirus infection in haemopoietic stem cell transplantation

May 2013

These evidence-based guidelines expand and adapt previous guidance (Tomblyn et al, 2009; Andrews et..

... al, 2011). While specifically focusing on allogeneic haemopoietic stem cell transplantation (HSCT), they are relevant to other areas of haematological oncology where there is an increased risk of cytomegalovirus (CMV) infection, such as haematological cancers where intense anti-T-cell therapy has been deployed (O’Brien et al, 2006).

ESCMID guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT)

Dec 2012

Fungal diseases still play a major role in morbidity and mortality in patients with haematological..

... malignancies, including those undergoing haematopoietic stem cell transplantation. Although Aspergillus and other filamentous fungal diseases remain a major concern, Candida infections are still a major cause of mortality. This part of the ESCMID guidelines focuses on this patient population and reviews pertaining to prophylaxis, empirical/pre-emptive and targeted therapy of Candida diseases. AntiCandida prophylaxis is only recommended for patients receiving allogeneic stem cell transplantation.

Clinical Trials

MSC Therapy in Liver Transplantation

06-10-2014

The general aim of the present study is to test a cell therapy with third-party allogeneic ex-vivo expanded MSCs as a strategy to induce tolerance in liver transplant recipients. MSCs will be prepared accordingly to established protocols , starting from..

... diagnostic samples of bone marrow aspirates (2-5 mL) or using the remnants in the bag and filter at the end of the bone marrow infusions. From these samples, MSCs will be expanded in GMP approved facilities and used for the present study in patients undergoing liver transplantation.

Detection of Acute Graft Rejection by Estimation of T2 (DRAGET)

25-09-2014

The investigators propose a simple and non-invasive method to monitor heart transplant patients with MRI. Its diagnostic and prognostic values have already been assessed in two monocentric studies. Other monocentric studies based on related methods have..

... confirmed the investigators findings. These studies are insufficient to allow a large diffusion of the technique. Only a large multi-centric study will change medical practices. In addition, this project will spread the new method at a national level and will allow an assessment of its practical usefulness in centres not familiar with MRI T2 quantification.

Furthermore, MRI seems to detect rejections at earlier stage than biopsy. A confirmation of this observation could lead to a modification of diagnostic criteria of cardiac graft rejection. The ultimate aim of the DRAGET project is to replace a strategy based solely on biopsy with one based on a first-line MRI (with biopsy only when needed) for a more efficient and earlier detection of rejection. This would constitute a major advance in patients security and comfort as well as an economic improvement.

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