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Latest News

Medical Videos

An Overview of Blood Transfusions
An Overview of Blood Transfusions
Corneal Transplant - The Diseases, Procedures and Success Rates
Corneal Transplant - The Diseases, Procedures and Success Rates
Heart Transplantation - The Reasons for Transplantation and the Success Rates
Heart Transplantation - The Reasons for Transplantation and the Success Rates
Lung Transplants - The Benefits and Limitations
Lung Transplants - The Benefits and Limitations

Recent Drug Updates

Medical Journal Abstracts on Transplantation

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure.

Fri 29 Jan 2016 -  Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure.

Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). Untreated ...

Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease.

Thu 07 Jan 2016 -  Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease.

Background: Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that the inclusion of ...

Clinical Guidelines

EASL Clinical Practice Guidelines: Liver transplantation

Nov 2015

The first human orthotopic liver transplantation (LT) in Europe was performed by Sir Roy Calne in..

... Cambridge in 1968, only one year after the first successful human liver transplantation reported by Thomas Starzl in the United States. Since then LT has evolved rapidly, becoming the standard therapy for acute and chronic liver failure of all aetiologies, with more than 80,000 procedures performed to date. Survival rates have improved significantly in the last 25 years, achieving rates of 96% and 71% at 1 and 10 years after LT respectively.

This great success is mostly attributable to several advances such as the introduction of new immunosuppressive agents and preservation solutions, to the improvements in surgical techniques and to the early diagnosis and management of complications after LT. As a consequence of these achievements, indications for LT have been expanded resulting in a growing demand for transplantable grafts and in a dramatic organ shortage. Therefore, one of the main ongoing challenges the transplant community is facing is to expand the donor pool in order to minimize the rate of patient death on the waiting list. On the other hand, liver transplanted patients are surviving longer after the operation and long-term outcomes are becoming the main concern for clinicians, who have to deal with direct and indirect side effects of immunosuppressive therapy.

This Clinical Practice Guideline (CPG) has been developed to assist physicians and other healthcare providers during the evaluation process of candidates for LT and to help them in the correct management of patients after LT.

Management of cytomegalovirus infection in haemopoietic stem cell transplantation

Jul 2013

These evidence-based guidelines expand and adapt previous guidance (Tomblyn et al, 2009; Andrews et..

... al, 2011). While specifically focusing on allogeneic haemopoietic stem cell transplantation (HSCT), they are relevant to other areas of haematological oncology where there is an increased risk of cytomegalovirus (CMV) infection, such as haematological cancers where intense anti-T-cell therapy has been deployed (O’Brien et al, 2006).

Clinical Trials

Safety and Efficacy of BL-8040 for the Mobilization of Donor Hematopoietic Stem Cells and Allogeneic Transplantation in Patients With Advanced Hematological Malignancies

Tue 01 Mar 2016

Current protocols use G-CSF to mobilize hematopoietic progenitor cells from matched sibling and volunteer unrelated donors. Unfortunately, this process requires four to six days of G-CSF injection ...

Human Umbilical Cord-derived Mesenchymal Stem Cells With Injectable Collagen Scaffold Transplantation for Chronic Ischemic Cardiomyopathy

Thu 01 Oct 2015

The study is designed to assess the safety and efficacy of allogeneic human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) with injectable collagen scaffold transplanted into patients with ...

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