Transplantation Topic Homepage

Anti-Infectives Knowledge Network IFI

,AIKN IFI

The Anti-infectives Knowledge Network – Invasive Fungal Infections (AIKN-IFI), an initiative by Astellas Pharma EMEA, shares the expertise and experience of a number of thought leaders in the disease therapy area of Anti-infectives.

Most recent updates with content from the 20th Annual International Liver Transplantation Society (ILTS) Congress which included an interactive case discussion presented by Carlos Cervera - 'Focus on candidaemia'.

News reports and sponsored presentations from this year: ECCMID, EBMT, ASM, ISICEM, AAA.

Also available - Free downloadable ESCMID Guidelines Supplement for the diagnosis and management of Candida diseases and related slides for use in your own presentations.

Please remember to return regularly to read the news, clinical insights, and essential information from the latest congresses.

Click here to enter the AIKN-IFI

Anti-Infectives Knowledge Network CDI

,AIKN CDI

The Anti-infectives Knowledge Network – Clostridium difficile Infections (AIKN-CDI), an initiative by Astellas Pharma EMEA Ltd., shares the expertise and experience of a number of thought leaders in the disease therapy area of Anti-infectives.

Most recent updated with content from ID Week 2014, these reports detail the national estimates of CDI incidence in the USA, how to predict the risk of CDI and the burden that recurrent CDI brings to healthcare settings.  

News reports and sponsored presentations from this year: ICAAC ECCMID, EBMT, and ISICEM.

Also available – Interative annotated treatment guidelines for the management of Clostridium difficile infection.

Please remember to return regularly to read the news, clinical insights, and essential information from the latest CDI congresses.

Click here to enter the AIKN-CDI.

Medical Videos

Heart Transplantation - The Reasons for Transplantation and the Success Rates
Heart Transplantation - The Reasons for Transplantation and the Success Rates
Corneal Transplant - The Diseases, Procedures and Success Rates
Corneal Transplant - The Diseases, Procedures and Success Rates
Lung Transplants - The Benefits and Limitations
Lung Transplants - The Benefits and Limitations
An Overview of Blood Transfusions
An Overview of Blood Transfusions

Recent Drug Updates

Medical Journal Abstracts on Transplantation

Living vs. Deceased Donor Liver Transplantation Provides Comparable Recovery of Renal Function in Patients With Hepatorenal Syndrome: A Matched Case–Control Study

Thu 02 Oct 2014 -  American Journal of Transplantation

Outcomes of living versus deceased donor liver transplantation in patients with chronic liver disease and hepatorenal syndrome (HRS) was compared using a matched pair study design. Thirty patients ...

Analysis of factors affecting immune recovery and initial response to tetanus after DTaP vaccination in pediatric allogeneic HSCT patients

Sun 21 Sep 2014 -  Pediatric Transplantation

Transfer of donor immunity after allo-HSCT is limited, requiring re-vaccination after HSCT. The CDC 2009 guidelines introduced earlier vaccination post-HSCT with a uniform vaccination strategy. This ...

Clinical Guidelines

Management of cytomegalovirus infection in haemopoietic stem cell transplantation

May 2013

These evidence-based guidelines expand and adapt previous guidance (Tomblyn et al, 2009; Andrews et..

... al, 2011). While specifically focusing on allogeneic haemopoietic stem cell transplantation (HSCT), they are relevant to other areas of haematological oncology where there is an increased risk of cytomegalovirus (CMV) infection, such as haematological cancers where intense anti-T-cell therapy has been deployed (O’Brien et al, 2006).

ESCMID guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT)

Dec 2012

Fungal diseases still play a major role in morbidity and mortality in patients with haematological..

... malignancies, including those undergoing haematopoietic stem cell transplantation. Although Aspergillus and other filamentous fungal diseases remain a major concern, Candida infections are still a major cause of mortality. This part of the ESCMID guidelines focuses on this patient population and reviews pertaining to prophylaxis, empirical/pre-emptive and targeted therapy of Candida diseases. AntiCandida prophylaxis is only recommended for patients receiving allogeneic stem cell transplantation.

Clinical Trials

MSC Therapy in Liver Transplantation

06-10-2014

The general aim of the present study is to test a cell therapy with third-party allogeneic ex-vivo expanded MSCs as a strategy to induce tolerance in liver transplant recipients. MSCs will be prepared accordingly to established protocols , starting from..

... diagnostic samples of bone marrow aspirates (2-5 mL) or using the remnants in the bag and filter at the end of the bone marrow infusions. From these samples, MSCs will be expanded in GMP approved facilities and used for the present study in patients undergoing liver transplantation.

Detection of Acute Graft Rejection by Estimation of T2 (DRAGET)

25-09-2014

The investigators propose a simple and non-invasive method to monitor heart transplant patients with MRI. Its diagnostic and prognostic values have already been assessed in two monocentric studies. Other monocentric studies based on related methods have..

... confirmed the investigators findings. These studies are insufficient to allow a large diffusion of the technique. Only a large multi-centric study will change medical practices. In addition, this project will spread the new method at a national level and will allow an assessment of its practical usefulness in centres not familiar with MRI T2 quantification.

Furthermore, MRI seems to detect rejections at earlier stage than biopsy. A confirmation of this observation could lead to a modification of diagnostic criteria of cardiac graft rejection. The ultimate aim of the DRAGET project is to replace a strategy based solely on biopsy with one based on a first-line MRI (with biopsy only when needed) for a more efficient and earlier detection of rejection. This would constitute a major advance in patients security and comfort as well as an economic improvement.

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