Please note- The EPG Renal Anaemia Knowledge Centre is for Doctors and other Healthcare Professionals.
Enter the Renal Anaemia Knowledge Centre
MIRACEL is the first real-life study to investigate switching the treatment of Chronic Kidney Disease (CKD) patients on dialysis from commonly used shorter-acting erythropoiesis-stimulating agents (ESAs) directly to the once monthly administration of the drug Mircera®, using pre-filled syringes.
Initial results confirm that Mircera® maintains haemoglobin (Hb) levels in CKD patients within a narrow range. Read more about the MIRACEL study results
Chronic Kidney Disease (CKD) is characterised by a gradual and permanent loss of kidney function that worsens as it progresses from stages 1 to 5. One of the most common complications of CKD is anaemia. Anaemia in patients with CKD causes debilitating weakness and fatigue, altered cognitive function, and a negative impact on quality of life and wellbeing.1
Anaemia is defined as a reduction of the number of circulating red blood cells to below a certain threshold level. It is also described as a low haemoglobin concentration or a low volume of packed red cells2.
Renal anaemia is secondary to chronic kidney disease (CKD) and it appears early in the course of CKD, worsening as it progresses.
Because renal anaemia impairs the delivery and utilization of oxygen to tissues and organs throughout the body, it has a wide range of effects on both quality of life and overall health and well being.2
CKD-related anaemia is a major public health concern. It is associated with an increased risk of morbidity, mortality and hospitalisation, diminished physical well-being and reduced patient quality of life.3-6
Diagnosing renal anaemia is critical in establishing early and appropriate treatment in patients.
There are a number of treatment guidelines available which provide information on the management of anaemia and CKD related anaemia. Treatment of renal anaemia can significantly improve overall health in patients with chronic kidney disease (CKD).
What’s in the Renal Anaemia Knowledge Centre?
- Epidemiology of CKD
- Incidence and Prevalence of Stage 5 CKD
- Treatment of CKD
- Renal Anaemia: Definition
- Associated Symptoms
- CKD and Anaemia
- CKD and renal Anaemia
- Implications of CKD related anaemia
- Diagnosis: Overview
- Haemoglobin levels in renal anaemia
- Diagnostic flow chart
- Diagnostic tests: Establishing the cause of anaemia
- Diagnostic tests: Determining kidney function
- Diagnostic tests: Comorbidities tests
- Anaemia Treatment In CKD Patients
- Current Challenges in the Management of CKD-Related Anaemia
- Introducing MIRCERA
- mode of action
- Clinical Study highlights
- Treatment guidelines
- Current issues in anaemia management
- Useful External Links
- Bone marrow
- Chronic hypoxaemic pulmonary disease
- Chronic kidney disease
- CKD-related anaemia
- Complete blood count
- Correction therapy
- Disordered growth signals
- End-stage renal disease (ESRD)
- Inhibitory concentration (IC50)
- Kidney failure
- Left ventricular hypertrophy (LVH)
- Maintenance therapy
- Pathological organ function
- Pure red cell aplasia (PRCA)
- Red blood cell (erythrocyte)
- Renal anaemia Anaemia
- Reticulocyte count
- Titration period
- Vitamin B12
1. Lefebvre P, Vekeman F, Sarokhan B, Enny C, Provenzano R, Cremieux PY. Relationship between hemoglobin level and quality of life in anemic patients with chronic kidney disease receiving epoetin alfa. Curr Med Res Opin. 2006;22:1929-1937.
2. NAAC (National Anemia Action Council) Anemia monograph. Available at http://anemia.org/professionals/monograph/ [Accessed June 2008].
3. Foley RN, Parfrey PS, Harnett JD, Kent GM, Murray DC, Barre PE. The impact of anemia on cardiomyopathy, morbidity, and and mortality in end-stage renal disease. Am J Kidney Dis. 1996;28:53–61.
4. Levin A, Thompson CR, Ethier J, Carlisle EJ, Tobe S, Mendelssohn D, Burgess E, Jindal K, Barrett B, Singer J, Djurdjev O. Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin. Am J Kidney Dis. 1999;34:125–134.
5. Ofsthun N, Labrecque J, Lacson E, Keen M, Lazarus JM. The effects of higher hemoglobin levels on mortality and hospitalization in hemodialysis patients. Kidney Int. 2003;63:1908–1914.
6. Perlman RL, Finkelstein FO, Liu L, Roys E, Kiser M, Eisele G, Burrows-Hudson S, Messana JM, Levin N, Rajagopalan S, Port FK, Wolfe RA, Saran R. Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study. Am J Kidney Dis. 2005;45:658–666.
Early identification and management of chronic kidney disease in adults in primary and secondary careNational Institute for Health and Care Excellence (NICE)
Multicenter Study Comparing Taxotere Plus Curcumin Versus Taxotere Plus Placebo Combination in First-line Treatment of Prostate Cancer Metastatic Castration Resistant (CURTAXEL)Clinicaltrials.gov 20 March 2014
Effect of a Phosphate Modified Diet on Phosphate Balance and Phosphate Metabolism in Predialysis Patients Stage 3-4Clinicaltrials.gov 25 February 2014
Long-term Tolerability and Efficacy of Degarelix: 5-Year Results From a Phase III Extension Trial With a 1-arm Crossover From Leuprolide to DegarelixUrology 27 March 2014
Novel effect of the inhibitor of mitochondrial cyclophilin D activation, N–methyl–4–isoleucine cyclosporin, on renal calcium crystallizationInternational Journal of Urology 24 March 2014
- NEBIDO 1000 MG/4ML
- CYSTRIN 5MG TABLETS
- GYNO-PEVARYL 1 VAGINAL PESSARY
- UTINOR TABLETS
- SELEXID TABLETS
- XATRAL XL 10MG (BPH)
- SPORANOX CAPSULES
- NUTRINEAL PD4
- DETRUSITOL XL 4MG
- COMBODART 0.5 MG / 0.4 MG HARD CAPSULES
- BUSCOPAN AMPOULES
- DETRUSITOL 1MG & 2MG FILM-COATED TABLETS
- PRAZOSIN (BPH)
- DITROPAN TABLETS 2.5MG, DITROPAN TABLETS 5MG
- PROSCAR (BPH)
- OXYBUTYNIN HYDROCHLORIDE 3MG TABLETS
- MACROBID CAPSULES 100MG B.P.
- DESMOTABS 0.2MG
- FLOMAX RELIEF MR
- TOLTERODINE TARTRATE 1 MG FILM-COATED TABLET
- MIRCERA SOLUTION FOR INJECTION
- DETRUNORM 15 MG TABLETS
- CYSTAGON 150 MG HARD CAPSULES
- FABRAZYME 35 MG SOLUTION FOR INFUSION
- FARAMSIL 400 MICROGRAM PROLONGED-RELEASE TABLETS
- NIZORAL TABLETS
- MACRODANTIN CAPSULES 100MG B.P.
- XATRAL SR (BPH)
- CYMALON CRANBERRY LIQUID
- EMSELEX PROLONGED-RELEASE TABLETS
- EVEROSE 660 MG FILM-COATED TABLETS
- FABRAZYME 5 MG SOLUTION FOR INFUSION
- DORALESE TILTAB TABLETS 20 MG
- FLOMAXTRA XL, 400 MICROGRAMS
- LYRINEL XL TABLET
- CARDURA TABLETS
- FUROSEMIDE INJECTION BP 10MG/ML, 2ML, 5ML & 25ML
- XATRAL (BPH)
- HYPOVASE (BPH)
- GEMZAR 200MG POWDER FOR SOLUTION FOR INFUSION, GEMZAR 1000MG POWDER FOR SOLUTION FOR INFUSION
- FURADANTIN TABLETS 100MG
- PINEXEL PR 400 MICROGRAMS PROLONGED-RELEASE HARD CAPSULES
- BLERONE XL 4MG PROLONGED-RELEASE CAPSULES
- REPLAGAL 1 MG/ML CONCENTRATE FOR SOLUTION FOR INFUSION.
- NORFLOXACIN (GENERIC)
- YENTREVE 20MG AND 40MG HARD GASTRO-RESISTANT CAPSULES
- NEORECORMON (POWDER AND SOLVENT)
- VESICARE 5MG & 10MG FILM-COATED TABLETS
- AVODART 0.5MG SOFT CAPSULES
- NYSTAN ORAL SUSPENSION
- AVODART 0.5MG SOFT CAPSULES
- WARTICON CREAM
- TOVIAZ TABLETS