Renal Anaemia

Please note- The EPG Renal Anaemia Knowledge Centre is for Doctors and other Healthcare Professionals.
Enter the Renal Anaemia Knowledge Centre

MIRACEL is the first real-life study to investigate switching the treatment of Chronic Kidney Disease (CKD) patients on dialysis from commonly used shorter-acting erythropoiesis-stimulating agents (ESAs) directly to the once monthly administration of the drug Mircera®, using pre-filled syringes.

Initial results confirm that Mircera® maintains haemoglobin (Hb) levels in CKD patients within a narrow range. Read more about the MIRACEL study results

Chronic Kidney Disease (CKD) is characterised by a gradual and permanent loss of kidney function that worsens as it progresses from stages 1 to 5. One of the most common complications of CKD is anaemia. Anaemia in patients with CKD causes debilitating weakness and fatigue, altered cognitive function, and a negative impact on quality of life and wellbeing.1

Renal Anaemia Knowledge Centre

Anaemia is defined as a reduction of the number of circulating red blood cells to below a certain threshold level. It is also described as a low haemoglobin concentration or a low volume of packed red cells2.

Renal anaemia is secondary to chronic kidney disease (CKD) and it appears early in the course of CKD, worsening as it progresses.

Because renal anaemia impairs the delivery and utilization of oxygen to tissues and organs throughout the body, it has a wide range of effects on both quality of life and overall health and well being.2

CKD-related anaemia is a major public health concern. It is associated with an increased risk of morbidity, mortality and hospitalisation, diminished physical well-being and reduced patient quality of life.3-6

Diagnosing renal anaemia is critical in establishing early and appropriate treatment in patients.

The priority in the treatment of anaemia is to correct the underlying factors that caused the anaemia and the specific treatment strategy depends on the cause of the anaemia.

There are a number of treatment guidelines available which provide information on the management of anaemia and CKD related anaemia. Treatment of renal anaemia can significantly improve overall health in patients with chronic kidney disease (CKD).

Enter the Renal Anaemia Knowledge Centre

What’s in the Renal Anaemia Knowledge Centre?

References:
1. Lefebvre P, Vekeman F, Sarokhan B, Enny C, Provenzano R, Cremieux PY. Relationship between hemoglobin level and quality of life in anemic patients with chronic kidney disease receiving epoetin alfa. Curr Med Res Opin. 2006;22:1929-1937.
2. NAAC (National Anemia Action Council) Anemia monograph. Available at http://anemia.org/professionals/monograph/ [Accessed June 2008].
3. Foley RN, Parfrey PS, Harnett JD, Kent GM, Murray DC, Barre PE. The impact of anemia on cardiomyopathy, morbidity, and and mortality in end-stage renal disease. Am J Kidney Dis. 1996;28:53–61.
4. Levin A, Thompson CR, Ethier J, Carlisle EJ, Tobe S, Mendelssohn D, Burgess E, Jindal K, Barrett B, Singer J, Djurdjev O. Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin. Am J Kidney Dis. 1999;34:125–134.
5. Ofsthun N, Labrecque J, Lacson E, Keen M, Lazarus JM. The effects of higher hemoglobin levels on mortality and hospitalization in hemodialysis patients. Kidney Int. 2003;63:1908–1914.
6. Perlman RL, Finkelstein FO, Liu L, Roys E, Kiser M, Eisele G, Burrows-Hudson S, Messana JM, Levin N, Rajagopalan S, Port FK, Wolfe RA, Saran R. Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study. Am J Kidney Dis. 2005;45:658–666.

Related Urological and Kidney Diseases Information

Urological and Kidney Diseases Clinical Guidelines

Diagnosis and management of chronic kidney disease

Scottish Intercollegiate Guidelines Network (SIGN)

Anaemia management in chronic kidney disease

National Institute for Health and Care Excellence (NICE)

Urological and Kidney Diseases Clinical Trials

HDR vs LDR Brachytherapy as Monotherapy in the Treatment of Localized Prostate Cancer. (PROMOBRA)

Clinicaltrials.gov 30 September 2014

Intervention Trial Evaluating Focal Therapy Using High Intensity Focused Ultrasound for the Treatment of Prostate Cancer

Clinicaltrials.gov 29 September 2014

Urological and Kidney Diseases Medical Journal Abstracts

The Relationship Between Prostate Cancer and Presence of Metabolic Syndrome and Late-onset Hypogonadism

Urology 30 September 2014

Anesthetic Exposure in the Treatment of Symptomatic Urinary Calculi in Pregnant Women

Urology 30 September 2014

Urological and Kidney Diseases Medical Apps

ESMO Cancer Guidelines

Free

ESMO Cancer Guidelines par European Society for Medical Oncology

Free

Urological and Kidney Diseases News

Launch of Prostate Cancer Learning Hub

07 Oct 2014

Rayaldee meets endpoints in Phase III trial for CKD-OPKO Health

24 Sep 2014

Related Urological and Kidney Diseases Drugs

Back to top

Latest News

07 Oct 2014
24 Sep 2014
19 Sep 2014