Treatment
Other Therapeutic Approaches
Several other approaches to the treatment of CML are also under investigation. These include new transplant strategies and novel agents. Many of these are entering clinical trials, and some have shown encouraging activity. These new strategies include:
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Inhibition of gene expression
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Immunomodulation
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Novel tyrosine kinase inhibitors (TKIs)
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Recently approved dasatinib
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Others in development, including nilotinib (AMN107)
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Other agents under investigation for the treatment of CML include:
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Polyethylene glycol interferon alfa (IFN-α; PEG interferon)
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Decitabine
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Homoharringtonine (HHT)
Other transplantation approaches under investigation for the treatment of CML include:
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Autologous SCT
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Reduced intensity conditioning SCT
The precise role of these additional therapeutic options in the management of CML is yet to be defined.