Zomig

^†defined as a 1 point drop in headache intensity

Efficacy - Zomig is Effective and Long Lasting

• Zomig is effective if taken anytime a migraine headache strikes⁴
• Zomig is effective at anytime during a migraine attack⁵
• One Zomig 2.5mg tablet provides relief for up to 24 hours in the majority of responders*⁶
• 95% of attacks treated with Zomig 2.5mg have a headache response within 2 hours in the typical patient (as defined by the median response^† )⁷

Number Of Responders In A Typical Patient Population

* following a response at 2 hours
^† for each patient the percentage of headaches treated successfully with Zomig 2.5mg was calculated, with success being a reduction in headache intensity from moderate or severe at baseline to mild or none following treatment. The median of these individual patient successrates was then determined to represent the overall median response rate.

Consistent Relief

• Zomig - a predictable treatment for an unpredictable disease
• Zomig is consistently effective in treating multiple migraineattacks in individual patients⁷
• In a one year long-term open label study, Zomig 2.5mg was consistently effective in treating up to 25 attacks.

	‘Zomig’ 2.5mg: reliable 2 hour headache response* rates across attacks	All Attacks 85% (n=11944)
* headache response defined as moderate or severe headache at baseline decreasing to mild or none at 2 hours.
	‘Zomig’ 2.5mg: reliable 2 hour pain free*rates across attacks	All Attacks 69% (n=14553)
* pain free defined as mild, moderate or severe headache at baseline decreasing to none at 2 hours.

Tolerance- Zomig is Well Tolerated

• Zomig 2.5mg - excellent tolerability without compromising efficacy
• Zomig 2.5mg - adverse events typically mild or moderate and resolve spontaneously without intervention⁸
• Zomig 2.5mg - incidence of severe adverse events similar to placebo⁸
• Zomig 2.5mg - available in over 70 countries worldwide.
• Zomig Rapimelt' is well tolerated with an adverse event profile similar to that of the Zomig 2.5mg tablet ⁹

Profile of adverse events seen in clinical trials with‘Zomig’ 2.5mg and placebo

Simple to Prescribe

• Zomig has a simple dosing schedule - 2.5mg standard dose
• Zomig can be taken with or without food and absorption is unaffected by food¹⁰
• Zomig can be taken with a range of commonly co-prescribed anti-migraine medications, including propranolol, pizotifen and paracetemol and/or metoclopramide⁵
• Zomig works across migraine subtypes response⁵

Two hour headache response rates across migraine subtypes with ‘Zomig’ 2.5mg5

Patient Friendly

• The majority of patients prefer to take Zomig Rapimelt than conventional tablets³
• Zomig Rapimelt is a convenient, new and unique formulation that disperses in seconds on the tongue and may be taken without liquid.
• 80% of migraine patients like the taste of orally disintegrating tablets³

Satisfaction with orally disintegrating tablets<5

References
1. Mauskop, Pfaffenrath and Tepper. Zolmitriptan: reliable relief of migraine symptoms with an early onset of action. Headache 1999; 39 (5): 368.
2. Ryan et al. Efficacy of zolmitriptan at early time points for the acute treatment of migraine and treatment of recurrence. CNS Drugs 2000: 13 (3); 215-226.
3. Dowson, MacGregor and Purdy. Efficacy and safety of zolmitriptan 2.5mg orally disintegrating tablet for the acute treatment of migraine. Poster presented at Headache World 2000, London 3-7 September 2000.
4. Cady and Matthew. Long-lasting migraine relief with Zomig (zolmitriptan) for attacks with onset at different periods of the day. Headache Quarterly 2000; 11(1): 55. Abstract and poster presented at the Postgraduate Course, Headache Update 1999, Lake Buena Vista, 20-24 July1999.
5. Schoenen and Sawyer. Zolmitriptan (Zomig, 311C90), a novel dual central and peripheral 5-HT1B/1D agonist: an overview of efficacy. Cephalalgia 1997; 17 (Suppl 18): 28-40.
6. Rapoport and Ryan. Zolmitriptan provides rapid and sustained relief of migraine headache. Cephalalgia 1999; 19(4): 370-371 Abs II-G1-51. Abstract and poster presented at the 9th Congress of the International Headache Society,Barcelona 22-26 June 1999.
7. Tuchman et al. Zolmitriptan provides consistent migraine relief when used in the long-term.Current Medical Resaearch and Opinion 1999; 15(4): 272-81
8. US Prescribing Information.
9. Purdy, Dowson and Sawyer. Zolmitriptan Orally Disintegrating Tablets are well tolerated and preferred over conventional tablets. Headache 2000; 40(5): 425. Poster presented at the 42nd Annual Scientific Meeting of the American Headache Society, Montreal, 23-25 June 2000.
10. Peck, Seaber, Smith et al. The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers. British Journal of Clinical Pharmacology 1998; 46(5): 433-439.