Hypertension Knowledge Centre
Angiotensin II Antagonists
Dosage and administration of eprosartan
Eprosartan is available as film coated, white oval shaped (300mg), or pink oval shaped (400mg) tablets, or white capsule shaped (600mg) tablets for oral administration.
The recommended starting and maintenance dose for most patients is 600mg once-daily, to be taken in the morning. Achievement of maximal blood pressure reduction usually takes 2 to 3 weeks of treatment.
Doses up to 1200mg per day, for 8 weeks, have been shown in clinical trials to be effective with no apparent dose relationship in the incidence of adverse experiences reported.
Eprosartan may be used alone or in combination with other anti-hypertensives, e.g. thiazide-type diuretics, calcium channel blockers, if a greater blood pressure lowering effect is required. Eprosartan may be taken with or without food.
Elderly
No dose adjustment is required in the elderly.
Dosage in hepatically impaired patients
No dose adjustment is required in hepatic impairment.
Dosage in renally impaired patients
In patients with moderate or severe renal impairment (creatinine clearance <60 ml/min), the daily dose should not exceed 600mg.
Please consult National SmPC (Summary of Product Characteristics) before prescribing eprosartan.