Non-small Cell Lung Cancer

Causes

The causes of lung cancer are thought to be almost exclusively environmental, although susceptibility is modulated by protective elements such as genetic factors and diet.1 Cigarette smoking is thought to be responsible for 90% of lung cancer cases in the US and other countries where the use of tobacco is prevalent. The inhalation of ‘environmental tobacco smoke’, or passive smoking, has been estimated to cause 3,000 lung cancer deaths a year in the US.2 The remaining 10% of lung cancers are considered to be caused by occupational exposure (tar and soot, and metals such as arsenic and chromium), exposure to building materials (silicates and asbestos), radiation (radon, X-rays and gamma rays), outdoor air pollution (traffic, and especially diesel exhaust fumes and other airborne carcinogens) and indoor air pollution (produced by combustion for heating and cooking).1

References:
1. Alberg AJ, Samet JM. Epidemiology of lung cancer. Chest 2003;123:21S–49S.
2. US Environmental Protection Agency (EPA). Respiratory health effects of passive smoking: lung cancer and other disorders. EPA Publication No. 600/006F, Washington, DC: US Government Printing Office, 1992.
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