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Soft Tissue Sarcoma

Soft Tissue Sarcoma

Soft Tissue Sarcomas (STS) are malignant (cancerous) tumors that develop in tissues which connect, support, or surround other structures and organs of the body. Muscles, tendons (bands of fiber that connect muscles to bones), fibrous tissues, fat, blood vessels, nerves, and synovial tissues are types of soft tissue.

Management of soft tissue sarcoma depends on the stage of disease and histological subtype.1 Surgery is the mainstay of treatment for patients with localised disease and is often curative. However, as recurrence is likely to occur when tumour cells remain after surgery, adjuvant radiotherapy is often also considered, especially for patients with intermediate or high-grade tumours. Radiotherapy, uses high energy rays to help cure cancers, is also often administered for patients in whom surgery is inappropriate or who decline surgery.1

For soft tissue sarcomas, the specialist healthcare professional may recommend radiotherapy to shrink sarcomas before surgery, help stop the sarcoma returning after surgery, to help slow the growth rate of advanced sarcomas and help relieve symptoms.

Discover classification of sarcomas by histopathology, look at prevalence and more by visiting the The Soft Tissue Sarcoma Knowledge Centre.


References

  1. . Clark MA, Fisher C et al. (2005) “Soft-tissue sarcomas in adults.” N Engl JMed 353(7): 701–11.

Clinical Case Studies

Smoking Cessation

Respiratory Medicine & Allergy: Lung Cancer

Suma Kumar, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
The wife and daughter of a patient you are treating for lung cancer are concerned about their risk of developing cancer. The wife is an ex-smoker having stopped six months ago.

Amiodarone Pulmonary Toxicity

Respiratory Medicine & Allergy: Non granuloma interstitial lung disease

Elizabeth Hadley, Consultant Respiratory and General Physician, Barking, Havering and Redbridge Hospitals University NHS Trust, London, UK
Boris Lams, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK
Christopher Kosky, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London , UK

Case History
A 72-year-old woman presented to hospital with shortness of breath. Two years prior to presentation she had been commenced on amiodarone 200 mg a day for non-sustained ventricular tachycardia.

Medical Videos

Surviving Advanced Breast Cancer
Surviving Advanced Breast Cancer
Eribulin Trial Success
Eribulin Trial Success
In the podcast, Dr. Crawford describes current and upcoming options available to urologists for treating this group of patients.
In the podcast, Dr. Crawford describes current and upcoming options available to urologists for treating this group of patients.
New Developments in the Treatment of Breast Cancer
New Developments in the Treatment of Breast Cancer
An Overview of Pancreatic NET and the Available Treatments
An Overview of Pancreatic NET and the Available Treatments
Metastatic Breast Cancer - A Patient's View of Various Treatments Including Eribulin
Metastatic Breast Cancer - A Patient's View of Various Treatments Including Eribulin
Cancer Vaccines- Dr. Kelvin Lee
Cancer Vaccines- Dr. Kelvin Lee
HPV Vaccine
HPV Vaccine
An Animation Explaining the Development of Lymphoma
An Animation Explaining the Development of Lymphoma

Recent Drug Updates

Medical Journal Abstracts on Oncology

Targeting hypoxia in the treatment of small cell lung cancer

Tue 26 Aug 2014 -  Lung Cancer

Small cell lung cancer (SCLC) is an extremely aggressive disease for which minimal therapeutic improvements have been made over the last few decades. Patients still rely on non-targeted, ...

Clinical performance of Prostate Health Index (PHI) for prediction of prostate cancer in obese men: data from a multicenter European prospective study, PROMEtheuS project

Mon 18 Aug 2014 -  BJU International

Objectives: To test [-2]proPSA (p2PSA), p2PSA/fPSA (%p2PSA) and Prostate Health Index (PHI) accuracy in predicting prostate cancer (PCa) in obese men and to test whether PHI is more accurate than ...

Medical Images

Hypersensitivity Pneumonitis
Hypersensitivity Pneumonitis
Small Cell Lung Cancer (SCLC)
Small Cell Lung Cancer (SCLC)
Hematoxylin and eosin stain
Hematoxylin and eosin stain
Pulmonary nodule
Pulmonary nodule
Bronchogenic cyst
Bronchogenic cyst
Sarcoidosis - radiograph showing interstitial shadowing
Sarcoidosis - radiograph showing interstitial shadowing
Amiodarone Pulmonary Toxicity
Amiodarone Pulmonary Toxicity
Non-Small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer (NSCLC)
Sarcoidosis - chest radiograph
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Online CME

Clinical Review - Breast Cancer

This activity covers the aetiology, diagnosis and management of breast cancer.

No Blunting of Immunologic Response to Sipuleucel-T When Combined With Abiraterone Acetate Plus Prednisone in mCRPC

After participating in this activity, clinicians should be better able to: Describe the differences in immunologic end points between concurrent sipuleucel-T and abiraterone as compared with the sequential use of...

mCRPC: The Right Treatment for the Right Patient at the Right Time

This educational activity is intended for an international audience of non-US healthcare professionals, specifically oncologists and urologists involved in the treatment of patients with metastatic prostate cancer. The goal of...

Clinical Trials

Prevention of Thrombocytopenia in Glioblastoma Patients (PLATUM)

26-08-2014

Chemotherapy used in the treatment of primitive tumors of the central nervous system has a particularly important platelet toxicity compared to chemotherapy used for treatment of other tumors. Chemotherapy postponed for toxicity is often due to..

... thrombocytopenia (TP). The TP and/or the other anomalies of coagulation, which can be spontaneous (Rogers, 2004) or induced (Gerber, 2006) can have dramatic consequences:

- specifically neurological (intratumoral bleeding with particularly important neovascularization) with a functional aggravation and sometimes involvement of vital prognosis,
- digestive (Garcia-Rodiguez, 2001) in patients receiving long term treatment with corticoids (potential gastric toxicity).

The encouraging results from the EORTC/NCIC trial by Stupp (median survival among patients with newly diagnosed glioblastoma is 14.6 months with an estimated 5-year survival of 9, 8%), has changed the standard of care of these patients (Stupp et al., 2009). Patients with newly diagnosed, histologically confirmed glioblastoma receive radiotherapy (2 Gy given 5 days per week for 6 weeks, for a total of 60 Gy) plus continuous daily Temozolomide (75 mg per square meter of body-surface area per day, 7 days per week from the first to the last day of radiotherapy), followed by six cycles of adjuvant Temozolomide (TMZ) (150 to 200 mg per square meter for 5 days during each 28-day cycle). The Stupp regimen is currently the treatment of reference for glioblastoma and is used as a basis in various clinical studies with new agents.

This study aims to evaluate Romiplostim for the treatment of TP secondary to initial TMZ chemotherapy of glioblastomas.

Radium-223 in Combination With Enzalutamide

22-08-2014

This study aims to determine the safety and tolerability of Radium-223 when administered in combination with enzalutamide in progressive metastatic castrate-resistant prostate cancer.

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