Oncology Topic Homepage

Soft Tissue Sarcoma

Soft Tissue Sarcoma

Soft Tissue Sarcomas (STS) are malignant (cancerous) tumors that develop in tissues which connect, support, or surround other structures and organs of the body. Muscles, tendons (bands of fiber that connect muscles to bones), fibrous tissues, fat, blood vessels, nerves, and synovial tissues are types of soft tissue.

Management of soft tissue sarcoma depends on the stage of disease and histological subtype.1 Surgery is the mainstay of treatment for patients with localised disease and is often curative. However, as recurrence is likely to occur when tumour cells remain after surgery, adjuvant radiotherapy is often also considered, especially for patients with intermediate or high-grade tumours. Radiotherapy, uses high energy rays to help cure cancers, is also often administered for patients in whom surgery is inappropriate or who decline surgery.1

For soft tissue sarcomas, the specialist healthcare professional may recommend radiotherapy to shrink sarcomas before surgery, help stop the sarcoma returning after surgery, to help slow the growth rate of advanced sarcomas and help relieve symptoms.

Discover classification of sarcomas by histopathology, look at prevalence and more by visiting the The Soft Tissue Sarcoma Knowledge Centre.


References

  1. . Clark MA, Fisher C et al. (2005) “Soft-tissue sarcomas in adults.” N Engl JMed 353(7): 701–11.

Clinical Case Studies

Smoking Cessation

Respiratory Medicine & Allergy: Lung Cancer

Suma Kumar, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
The wife and daughter of a patient you are treating for lung cancer are concerned about their risk of developing cancer. The wife is an ex-smoker having stopped six months ago.

Small Cell Lung Cancer (SCLC)

Respiratory Medicine & Allergy: Lung Cancer

Oni Choudhury, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 62-year-old woman presented with a 2-3-month history of breathlessness, non-productive cough, weight loss, lethargy and ankle oedema. Her exercise tolerance was limited to 50 yards by breathlessness.

Medical Videos

Surviving Advanced Breast Cancer
Surviving Advanced Breast Cancer
In the podcast, Dr. Crawford describes current and upcoming options available to urologists for treating this group of patients.
In the podcast, Dr. Crawford describes current and upcoming options available to urologists for treating this group of patients.
Eribulin Trial Success
Eribulin Trial Success
New Developments in the Treatment of Breast Cancer
New Developments in the Treatment of Breast Cancer
Metastatic Breast Cancer - A Patient's View of Various Treatments Including Eribulin
Metastatic Breast Cancer - A Patient's View of Various Treatments Including Eribulin
An Overview of Pancreatic NET and the Available Treatments
An Overview of Pancreatic NET and the Available Treatments
HPV Vaccine
HPV Vaccine
Cancer Vaccines- Dr. Kelvin Lee
Cancer Vaccines- Dr. Kelvin Lee
An Animation Explaining the Development of Lymphoma
An Animation Explaining the Development of Lymphoma

Recent Drug Updates

Medical Images

Small Cell Lung Cancer (SCLC)
Small Cell Lung Cancer (SCLC)
Amiodarone Pulmonary Toxicity
Amiodarone Pulmonary Toxicity
Non-Small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer (NSCLC)
Sarcoidosis - radiograph showing interstitial shadowing
Sarcoidosis - radiograph showing interstitial shadowing
Sarcoidosis - chest radiograph
Sarcoidosis - chest radiograph
Hematoxylin and eosin stain
Hematoxylin and eosin stain
Hypersensitivity Pneumonitis
Hypersensitivity Pneumonitis
Pulmonary nodule
Pulmonary nodule
Bronchogenic cyst
Bronchogenic cyst

Clinical Guidelines

British HIV Association guidelines for HIV-associated malignancies 2014

Feb 2014

The overall purpose of these guidelines is to provide guidance on best clinical practice in the..

... treatment and management of adults with HIV infection and malignancy. The scope includes the management of diagnosed malignancies in people living with HIV but does not address screening for malignancies in this population. This is covered elsewhere in other BHIVA guidance where evidence is available to support it

Guidelines for the diagnosis and management of Multiple Myeloma 2014

Feb 2014

The objective of this guideline is to provide healthcare professionals with clear guidance on the..

... diagnosis and management of patients with multiple myeloma

Online CME

Clinical Review - Lung cancer

This activity covers the diagnosis and management of lung cancer.

A Clinical Review of Radionuclide Therapy in Prostate Cancer

This activity is intended for a target audience of oncologists, urologists, and nuclear medicine specialists. The goal of this activity is to provide a foundational overview of the role of...

Clinical Review - Breast Cancer

This activity covers the aetiology, diagnosis and management of breast cancer.

Clinical Trials

Assessing The Effectiveness of a Preoperative High Intensity Interval Training Programme In Older Colorectal Cancer Patients (HITCa)

10-07-2014

The primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in VO2peak, can be achieved within 31 days via HIT programme in a group of older, colorectal cancer patients.

Rotating Frame Relaxation and Diffusion Weighted Imaging of Human Gliomas (RODIG)

04-07-2014

Grading of gliomas is of significant clinical importance since the prognosis as well as the treatment of choice are distinct in low-grade and high-grade gliomas. With standard MRI modalities, however, a reliable distinction is often impossible. Moreover, the gold standard for glioma grading by histopathology may..

... also have limitations due to unrepresentative tumor samples. Therefore, more advanced MRI techniques are urgently needed that would have higher sensitivity and specificity in the definition of tumor type, grade and extent.

Assessment of radiologic response for high-grade gliomas utilizes the updated RANO criteria 12 weeks after completion of chemoradiotherapy. However, there is an urgent need to identify nonresponding patients earlier, preferentially midtreatment in order to consider alternative treatment strategies. Imaging biomarkers, such as diffusion weighted MR imaging (DWI), have provided promising results in assessing early treatment response. Furthermore, a serum biomarker with diagnostic value could improve tumor follow-up and clinical management of gliomas.

The aim of our study is to develop novel imaging protocols suitable for the magnetic resonance imaging (MRI) of glioma using advanced MRI techniques such as rotating frame imaging, novel DWI acquisition and post-processing methods We also study the correlation between advanced MRI parameters and histopathology of the tumor specimen. In addition, early treatment response is assessed with advanced MRI parameters at 3 week and 10 week after initiation of radiotherapy. Finally, our objective is to study the association between serum biomarkers and corresponding MRI with potential tumor progression.

Back to top