CHMP recommends Amyvid (Eli Lilly) for Alzheimers investigations - 21-Oct-2012

The Committee for Medicinal Products for Human Use (CHMP) has recommended marketing authorisation for Amyvid (florbetapir 18F) from Eli Lilly, as a diagnostic agent in patients who are being evaluated for Alzheimer’s disease (AD) and other causes of cognitive decline. Amyvid is a radiopharmaceutical agent used in positron emission tomography (PET) imaging in the brains of adults. It can highlight amyloid protein plaques in the brain, and assist in the diagnosis of AD.

Accurate diagnosis of AD has been hampered to date by the lack of diagnostic tests. The current gold standard for confirming a clinical diagnosis of AD is post-mortem autopsy, PET imaging using Amyvid can provide useful information on neuritic plaque density in the brains of patients who are being tested for cognitive decline.

Following intravenous injection, the radioactive agent Amyvid binds to ?-amyloid in the brain. ?-amyloid protein is present in the brains of people with AD and other cognitive disorders.Importantly, a negative Amyvid PET scan can rule out the presence of AD, and is expected to reduce the frequency of false positive diagnosis.