Success in Phase III SINGLE trial of Dolutegravir - 14-Jul-2012
Interim results from the Phase III SINGLE study involving dolutegravir from Shionogi-Viiv HealthCare,demonstrated superiority of the dolutegravir-based regimen compared to the single tablet regimen Atripla. At 48 weeks, 88% of study participants on the dolutegravir regimen were virologically suppressed (<50 copies/mL) vs. 81% of participants on the single tablet regimen Atripla: The difference in the primary endpoint was statistically significant. Differences in efficacy were primarily driven by a higher rate of discontinuation due to adverse events on the Atripla arm.
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