ODYSSEY Phase III trials enroll for SAR 236553 treatment of LDL Cholesterol - 22-Jul-2012
Sanofi and Regeneron Pharmaceuticals, Inc. announced that several trials within ODYSSEY, the Phase III clinical program of SAR236553/REGN727, have initiated patient enrollment. SAR236553/REGN727 is a potential first-in-class, subcutaneously administered, fully-human antibody that lowers low-density lipoprotein (LDL) cholesterol by targeting PCSK9 (proprotein convertase subtilisin/kexin type 9), an enzyme which binds LDL receptors, leading to their accelerated degradation and increased LDL-cholesterol (LDL-C) levels.
Related News
FDA approves Liptruzet (Merck Inc) for Dyslipidaemia
Tredaptive (Merck Inc) fails to meet primary end point in HPS2-THRIVE Dyslipidaemia trial
Phase IV study of Livalo (Eli Lilly/Kowa Pharmaceuticals) meets end point in patients with Dyslipidemia
Merck Inc,. withdraws Tredaptive treatment for Dyslipidaemia
Tredaptive (Merck Inc) fails in HPS2-THRIVE trial
AMG 134 success in GAUSS study in patients intolerant of statins
Epanova (Omthera Pharma) successes in EVOLVE and ESPIRIT trials for Dyslipidaemia
FDA Advisory Committee recommends Kynamro for treatment of Homozygous Familial Hypercholesterolemia
Related Cardiology Information
Cardiology Clinical Guidelines
Atrial fibrillation: National clinical guideline for management in primary and secondary care
NICEHypertension: management of hypertension in adults in primary care
NICECardiology Clinical Trials
A Pilot Study of a Novel Technique for Cardiac Resynchronisation Therapy to Treat Heart Failure (LV-CONSEPT)
Clinicaltrials.gov 19 March 2013A Study to Assess the Pharmacokinetics and Pharmacodynamics of JNJ-54452840 in Participants With Heart Failure and Anti-beta1-adrenergic Receptor Autoantibodies
Clinicaltrials.gov 22 February 2013Cardiology Medical Journal Abstracts
Local Versus Epidural Anesthesia in Fast-Track Abdominal Aortic Surgery
Journal of Cardiothoracic and Vascular Anesthesia 02 January 2013β-Blockers and Volatile Anesthetics May Attenuate Cardioprotection by Remote Preconditioning in Adult Cardiac Surgery: A Meta-analysis of 15 Randomized Trials
Journal of Cardiothoracic and Vascular Anesthesia 02 January 2013Cardiology Medical Apps
Cardiac CT imaging - Diagnosis of Cardiovascular disease
£3.99
Cardio3 ECHO Lite
Free
Related Cardiology Drugs
- BISOPROLOL 2.5MG/5MG/10MG FILM COATED TABLET
- LIPOSTAT
- XISMOX 60 XL PROLONGED RELEASE TABLETS
- AMLODIPINE 10MG TABLETS
- MODALIM
- TENSIPINE MR
- HYDRALAZINE AMPOULES
- CORDARONE X INTRAVENOUS
- INDIPAM XL
- MONOZIDE 10
- VISKEN TABLETS 5 MG
- CO-AMILOFRUSE 20/2.5MG TABLETS
- ORGARAN
- CORGARETIC 40
- RYTHMODAN RETARD
- SIMVASTATIN 20MG/5ML ORAL SUSPENSION
- PERSANTIN AMPOULES 10 MG/2 ML SOLUTION FOR INFUSION
- RASILEZ TABLETS
- UNIVER 180MG PROLONGED RELEASE CAPSULES
- ADVATE SOLUTION FOR INJECTION
- HELIXATE
- ZESTRIL 2.5MG, 5MG, 10MG, AND 20MG TABLETS.
- EPHEDRINE HYDROCHLORIDE
- VISKEN TABLETS 15 MG
- FERROUS SULPHATE TABLETS, COMPOUND
- CLOPIDOGREL 75 MG FILM-COATED TABLETS
- SECURON SR
- QUIXIDAR 1.5 ML/0.3 ML
- REOPRO
- KONAKION
- LIPOBAY
- ALDACTIDE 25MG AND 50MG TABLETS
- ZANIDIP 20 MG TABLETS
- PRITOR
- HAEMATE P 500 AND 1000 IU
- INNOZIDE
- ISTIN
- ZESTORETIC
- MYOVIEW
- NEOSPECT
- FRUMIL LS
- COLESTID
- ZOCOR 10MG, 20MG, 40MG AND 80MG FILM-COATED TABLETS
- TEKAMLO
- INDOCID PDA
- TAMBOCOR INJECTION
- VERTAB SR 240MG
- LASILACTONE
- SPIRONOLACTONE 100MG TABLETS
- CAPTO-CO
- ROGITINE
- NEUPOGEN
- LEUCOMAX
- PLETAL TABLETS
- REVATIO 20 MG FILM-COATED TABLETS
- ZAPAIN
- PHARMADREAMS - ENALAPRIL 10MG TABLETS
- ACCUPRO TABLETS 5MG, 10MG, 20MG & 40MG
- FERROUS GLUCONATE 300MG TABLETS
- APROTININ
- TENORMIN SYRUP
- METOPROLOL TARTRATE TABLETS BP 100MG
- SEVIKAR
- NOVOSEVEN
- ELANTAN (HEART FAILURE)
- OPTISON
- INOSITOL NICOTINATE
- MINITRAN
- APROVEL FILM-COATED TABLETS (SANOFI-AVENTIS BRISTOL-MYERS SQUIBB SNC)
- COVERSYL ARGININE PLUS TABLETS
- EPINEPHRINE [ADRENALINE] 1 IN 10, 000
- BETIM 10MG TABLETS
- NEPHRIL
- COZAAR 12.5 MG, 25 MG, 50 MG AND 100 MG FILM-COATED TABLETS
- ODRIK
- TARKA
- NAVIDREX
- COZAAR - COMP 50/12.5MG, 100/12.5MG AND 100/25MG FILM-COATED TABLETS
- SLOW TRASICOR
- ANGIOPINE MR
- TRIAM-CO
- LONITEN
- ARAMINE
- UNIVER 120MG PROLONGED RELEASE CAPSULES
- DILZEM SR
- ACETAZOLAMIDE 250MG TABLETS
- BARATOL
- STREPTASE 250,000 IU AND 750,000 IU
- INDERAL LA 160MG
- CORDARONE 100MG AND 200MG TABLETS
- KALTEN
- COVERSYL (HYPERTENSION)
- INDERETIC
- VENOFER
- PEDEA 5 MG/ML SOLUTION FOR INJECTION
- FRU-CO
- NIMOTOP 0.02% SOLUTION FOR INFUSION
- ISOKET RETARD
- APRINOX
- CELECTOL 200 TABLETS
- LOPRESOR SR
- BENDROFLUAZIDE
- TANATRIL
- NAVISPARE
- TRANDATE INJECTION
- SINTHROME
- ACTILYSE CATHFLO 2 MG
- FRUMIL
- COVERSYL ARGININE
- ADIZEM-SR TABLETS
- LISINOPRIL 2.5MG TABLETS
- ADRENALINE [EPINEPHRINE] 1 IN 1,000
- ENALAPRIL MALEATE/HYDROCHLOROTHIAZIDE 20/12.5MG TABLETS
- DIUREXAN TABLETS
- HALF INDERAL
- HEPARIN CALCIUM 25,000 I.U./ML SOLUTION FOR INJECTION OR CONCENTRATE FOR SOLUTION FOR INFUSION
- DIGOXIN TABLETS BP 62.5MCG, 125MCG, 250MCG
- TENORMIN INJECTION 0.5MG/ML
- TEVETEN 300MG AND 600MG FILM-COATED TABLETS
- LERCANIDIPINE HYDROCHLORIDE 20 MG FILM-COATED TABLETS
- OXPRENOLOL
- EUCARDIC 25MG TABLETS
- TRENTAL 400
- AMIL-CO
- STARIL (CARDIAC FAILURE)
- STROMBA
- RAMIPRIL 10MG TABLETS
- FERROUS SULPHATE TABLETS BP 200MG
- FORTIPINE LA 40MG MODIFIED-RELEASE TABLETS
- CENTYL K
- BETALOC I.V. INJECTION
- NEORECORMON (SOLUTION FOR INJECTION)
- PAROVEN
- CANDESARTAN CILEXETIL 16 MG TABLETS
- COAPROVEL
- EXFORGE 5MG/80MG, 5MG/160MG, 10MG/160MG FILM COATED TABLETS
- INSPRA 25MG & 50 MG FILM-COATED TABLETS
- PROPRANOLOL
- ASASANTIN RETARD
- QUIXIDAR 2.5 MG/0.5 ML
- DOBUTAMINE CONCENTRATE 250MG/20ML
- TRASIDREX
- HYGROTON
- SUPRALIP 160
- LISINOPRIL 20MG TABLETS
- SECTRAL 400MG TABLETS
- ISMO RETARD
- FRUSOL
- PRONESTYL
- CALCIUM CHLORIDE INTRAVENOUS INFUSION, 10% W/V
- CO-AMILOZIDE (AMILORIDE, HYDROCHLOROTHIAZIDE)
- CARDICOR 1.25MG, 2.5MG, 3.75MG, 5MG, 7.5MG, 10MG FILM COATED TABLETS
- CYKLOKAPRON INJECTION
- OMNIPAQUE
- ZANIDIP 10 MG TABLETS
- DISOPYRAMIDE
- PERSANTIN 100 MG TABLETS
- HEXOPAL
- LESCOL XL 80 MG PROLONGED RELEASE TABLETS
- VERAPAMIL (ANGINA)
- TENORMIN LS 50MG TABLETS
- PLAVIX 75MG TABLETS
- PREGADAY
- MODURETIC
- ANGIOPINE LA
- RYTHMODAN
- APRESOLINE TABLETS 25 MG
- ANGETTES 75
- DOBUTAMINE 5 MG/ML, SOLUTION FOR INFUSION
- MEXITIL
- VERAPAMIL (SVTS)
- SIMVASTATIN 10MG FILM-COATED TABLETS
- HYDROSALURIC
- DIGOXIN INJECTION BP 500 MICROGRAMS/2ML
- AMLOSTIN 10MG
- IMAZIN XL
- PERDIX
- IKOREL
- ISMELIN
- ASPIRIN 75 MG GASTRO-RESISTANT TABLETS
- DIOVAN 40MG FILM-COATED TABLETS
- AMLODIPINE 5MG TABLETS
- SUSCARD BUCCAL
- RAPISCAN (REGADENOSON)
- ALDACTONE 25MG, 50MG AND 100MG TABLETS
- SOTALOL HYDROCHLORIDE 80 MG AND 160MG TABLETS
- METENIX
- DOPACARD
- ADIZEM-XL
- NATRILIX
- COZAAR 2.5 MG/ML POWDER AND SOLVENT FOR ORAL SUSPENSION
- VIAZEM XL 120MG / 180MG / 240MG / 300MG / 360MG
- FLECAINIDE
- ISOKET INFUSION
- DIOVAN 320MG FILM-COATED TABLETS
- TILDIEM LA 200/300MG PROLONGED-RELEASE CAPSULES
- TRIAPIN
- HYPOLOC 5 MG TABLETS
- IMDUR
- TAMBOCOR XL CAPSULES
- VASCACE TABLETS
- NIMOTOP 30MG TABLETS
- ISOTARD XL
- SOLOC 5 MG TABLETS
- TOREM
- EUCARDIC 6.25MG TABLETS
- FERROUS SULPHATE ORAL SOLUTION
- APRESOLINE AMPOULES 20 MG
- INNOVACE
- AGGRASTAT
- LABETALOL HYDROCHLORIDE (HYPERTENSION)
- LASIX INJECTION 20MG/2ML
- PRIMACOR 1MG/ML SOLUTION FOR INJECTION
- CARACE (CARDIAC FAILURE)
- LOPRESOR (ANGINA)
- CLIVARINE
- CAPOZIDE TABLETS
- MONOCOR
- CELIPROLOL
- OPILON
- HYDRALAZINE TABLETS
- ACTILYSE
- ENALAPRIL MALEATE 5MG TABLETS
- SIMVADOR 10MG, 20MG, 40MG, 80MG
- ZEMTARD XL
- ADIPINE MR
- EUCARDIC 12.5MG TABLETS
- OLBETAM CAPSULES 250
- LIPANTIL MICRO
- RANEXA PROLONGED-RELEASE TABLETS
- SIMVASTATIN 40MG/5ML ORAL SUSPENSION
- CAPOTEN TABLETS 25 MG & 50 MG
- NITRONAL
- CARDENE 20 AND 30MG
- FIBROGAMMIN P
- ISIB
- OMACOR
- TRACLEER
- FLOLAN
- BEZALIP 200MG TABLETS
- NYOGEL 0.1% EYE GEL
- LOSARTAN POTASSIUM 50 MG FILM-COATED TABLETS
- ISOSORBIDE MONONITRATE 20MG TABLETS
- CRESTOR 5MG, 10MG, 20MG AND 40MG FILM-COATED TABLETS
- ACEBUTOLOL 100MG CAPSULES
- ELANTAN LA (ANGINA)
- ALPHAPARIN
- BETA-ADALAT
- MONIT
- CAPTOPRIL 12.5 MG, 25 MG AND 50 MG TABLETS
- FRUSENE
- ALDOMET TABLETS 250 MG
- KALSPARE
- DEBRISOQUINE
- CO-AMILOFRUSE TABLETS 5/40MG
- DIOVAN 40MG CAPSULES
- REPLENINE
- BEDRANOL 80MG SR CAPSULES
- REFLUDAN 50 MG POWDER FOR SOLUTION FOR INJECTION OR INFUSION
- DYTAC 50MG CAPSULES
- NITROLINGUAL
- DIXARIT (MENOPAUSAL DISORDERS)
- TRANDATE TABLETS
- TRITACE 2.5MG TABLETS
- DILTIAZEM HYDROCHLORIDE TABLETS 60MG
- NIFEDIPINE
- CELECTOL 400 TABLETS
- SIMVASTATIN 80MG
- AMIODARONE 100MG TABLETS
- ADENOCOR
- PLENDIL 2.5MG, PLENDIL 5MG AND PLENDIL 10MG
- SYSCOR MR
- DYAZIDE
- REFACTO AF POWDER AND SOLVENT FOR SOLUTION FOR INJECTION
- ADALAT
- FIRAZYR SOLUTION FOR INJECTION
- KOGENATE BAYER 500 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION (MEDIMOP)
- LOPRESOR (HYPERTENSION)
- NITROMIN
- CATAPRES TABLETS 300MCG
- LISINOPRIL 10MG TABLETS
- DEPONIT 5
- PHENYLEPHRINE INJECTION 1%
- INTEGRILIN
- AMIODARONE 200MG TABLETS
- ADIZEM-SR CAPSULES
- DEMSER
- ATENOLOL 100MG
- SECTRAL 100MG AND 200MG
- LESCOL (FLUVASTATIN* SODIUM) 20 MG AND 40 MG CAPSULES
- HYTRIN
- ARYTHMOL
- LIPITOR 10MG, 20MG, 40MG, 80MG TABLETS
- ANGITIL SR /XL
- KERLONE
- GEMFIBROZIL
- LOPID 300MG HARD CAPSULES & 600MG FILM-COATED TABLETS
- ADCIRCA
- REVASC
- ATENOLOL 25MG TABLETS
- CO-AMILOFRUSE 40/5MG TABLETS
- TILDIEM RETARD 90MG PROLONGED-RELEASE TABLETS, TILDIEM RETARD 120MG PROLONGED-RELEASE TABLETS
- GLYCERYL TRINITRATE
- TENORETIC
- NEO-NACLEX
- PHARMADREAMS - ENALAPRIL 20MG TABLETS
- CATAPRES AMPOULES
- TICLID
- METHYLDOPA
- MODURET 25
- NEBILET 5 MG TABLETS
- SOLIRIS SOLUTION FOR INFUSION
- VASOXINE
- ANGIOPINE
- SIMVASTATIN 40MG
- MOTENS TABLETS
- DIPYRIDAMOLE
- ADALAT 5
- AMIAS TABLETS
- PARMID XL 5 MG PROLONGED RELEASE TABLETS
- GLYCERYL TRINITRATE INJECTION
- TRANSIDERM-NITRO 5 AND 10
- ACCURETIC 10/12.5MG TABLETS
- TILDIEM 60MG MODIFIED-RELEASE TABLETS
- NU-SEALS 75
- ATENOLOL 50MG FILM-COATED TABLETS
- OCTANATE 100IU/ML
- SLOZEM
- METOPIRONE
- PROCORALAN
- EUDEMINE (HYPERTENSION)
- GOPTEN
- FELOTENS XL TABLETS
- PRESCAL
- CHOLESTAGEL FILM-COATED TABLETS
- EMCOR
- VERAPAMIL (HYPERTENSION)
- CATAPRES TABLETS 100MCG
- ELANTAN (ANGINA)
- BENEFIX 250 IU / 500 IU / 1 000 IU / 2 000 IU
- BEZALIP MONO / CALBERZOL XL
- NITROCINE
- TENORET 50
- TENBEN
- GRANOCYTE
- TAMBOCOR TABLETS
- ADALAT LA 30 MG PROLONGED-RELEASE TABLETS
- SOTACOR TABLETS
- CHEMYDUR 60XL
- GLYPRESSIN INJECTION
- PRESTIM TABLETS
- NATRILIX SR
- CORGARD TABLETS 80MG
- CARDURA XL TABLETS
- MULTAQ 400MG TABLETS
- TENIF
- MONOMAX SR
- CARACE 20 PLUS TABLETS
- NITRO-DUR
- EPINEPHRINE (ADRENALINE) INJECTION 1:10,000
- CARDENE SR 30 AND 45MG
- DOPAMINE 40 MG/ML STERILE CONCENTRATE
- PERCUTOL
- XIGRIS SOLUTION FOR INFUSION
- VISKALDIX TABLETS
- KABIKINASE
- LEXPEC
- CORACTEN XL (ANGINA)
- UNIVER 240MG PROLONGED RELEASE CAPSULES
- TELMISARTAN ACTAVIS 20 MG TABLETS
- WARFARIN
- OLMETEC PLUS FILM-COATED TABLETS
- EZETROL TABLETS
- SYTRON
- INDEREX
- ADALAT LA 20 MG PROLONGED-RELEASE TABLETS
- CO-BETALOC
- LANOXIN
- HEPSAL
- SECADREX
- FRAGMIN 10,000 IU/1 ML
- TRISENOX SOLUTION FOR INFUSION
- BEDRANOL 160MG SR CAPSULES
- PERSANTIN RETARD 200 MG
- GLYTRIN
- TRITACE TABLET TITRATION PACK
- AMIODARONE
Advert for Healthcare Professionals only