Neurological Disorders Topic Homepage

Learning Zones

,Hyperammonaemia Knowledge Centre

Hyperammonaemia is a metabolic disturbance characterised by an excess of ammonia in the blood, and can have wide-ranging effects on metabolic, neurological and gastrointestinal systems.

The Hyperammonaemia Knowledge Centre has been developed to raise awareness of this rare yet potentially deadly condition. Using this resource, healthcare professionals are encouraged to recognise the signs and symptoms of hyperammonaemia and begin the correct treatment immediately.

Content in this resource is divided into the following sections:

  • Disease Awareness: epidemiology, pathophysiology, signs & symptoms, etc.
  • Carglumic Acid: information on drug characteristics, clinical efficacy, safety/tolerability and more
  • Video Channel: expert video presentations from Orphan Europe’s satellite symposium ‘Hyperammonaemia: a true medical emergency' at EAPS 2012
  • Resources: links to expert centres, European societies, treatment guidelines and more
  • E-learning: healthcare professionals can test their knowledge with clinically useful and current information through a series of case studies
 

Register for FREE today to access this Learning Zone.

Clinical Case Studies

Pneumococcal Meningitis

Infection: Central Nervous System Infection

R. Andrew Seaton, MBChB, MD, DTM&H, FRCP (Edinburgh & Glasgow), Consultant in Infectious Diseases and General Medicine, Honorary Senior Lecturer, University of Glasgow, Brownlee Centre for Infectious Diseases and Tropical Medicine, Gartnavel General Hospital, Glasgow, UK

Case History
A 65-year-old lady was admitted to the emergency department having been found unconscious, febrile and incontinent of urine.

Meningococcal Meningitis

Infection: Community-acquired Bloodstream Infections

Christopher Duncan, Research Fellow, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

Case History
A 36-year-old woman was admitted with sudden-onset severe occipital headache, photophobia and vomiting. On physical examination she was afebrile, with obvious photophobia and neck stiffness but no skin rashes.

Latest News

Medical Videos

Does chronic venous insufficiency play a role in MS pathogenesis? Commentary (CONy 2010)
Does chronic venous insufficiency play a role in MS pathogenesis? Commentary (CONy 2010)
An Overview of Brain Surgery and the Current Understanding of Brain Function
An Overview of Brain Surgery and the Current Understanding of Brain Function

Recent Drug Updates

Medical Journal Abstracts on Neurological Disorders

Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.

Fri 22 Apr 2016 -  Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.

Background: Substantial concerns have been raised about the neuropsychiatric safety of the smoking cessation medications varenicline and bupropion. Their efficacy relative to nicotine patch largely ...

Clinical effectiveness and safety of powered exoskeleton-assisted walking in patients with spinal cord injury: systematic review with meta-analysis.

Tue 22 Mar 2016 -  Clinical effectiveness and safety of powered exoskeleton-assisted walking in patients with spinal cord injury: systematic review with meta-analysis.

Background: Powered exoskeletons are designed to safely facilitate ambulation in patients with spinal cord injury (SCI). We conducted the first meta-analysis of the available published research on ...

Medical Images

Optic atrophy
Optic atrophy
Cerebral asperglioma on T1-weighted cerebral MRI
Cerebral asperglioma on T1-weighted cerebral MRI
MRI of the lumbarsacral spine
MRI of the lumbarsacral spine
T1 transverse MR image from a white male who presented with increasing confusion
T1  transverse MR image from a white male who presented with increasing confusion
T2 (weighted) transverse MR image from a white male who presented with increasing confusion
T2 (weighted) transverse MR image from a white male who presented with increasing confusion
Contrast enhanced MRI head
Contrast enhanced MRI head
Cerebral atrophy
Cerebral atrophy
T1-weighted (top) Grase (bottom) MRIs
T1-weighted (top) Grase (bottom) MRIs
Circumscribed right frontal lobe ring-enhancing lesion
Circumscribed right frontal lobe ring-enhancing lesion
T1-weighted transverse cranial MRI
T1-weighted transverse cranial MRI

Clinical Guidelines

Guidelines on Neuro-Urology

Mar 2016

The European Association of Urology (EAU) Neuro-Urology Guidelines aim to provide information for..

... clinical practitioners on the incidence, definitions, diagnosis, therapy, and follow-up of neuro-urological disorders. These Guidelines reflect the current opinion of experts in this specific pathology and represent a state-of-the-art reference for all clinicians, as of the publication date.

Spinal injury: assessment and initial management

Feb 2016

This guideline covers the assessment and early management of spinal column and spinal cord injury..

... in pre-hospital settings (including ambulance services), emergency departments and major trauma centres. It covers traumatic injuries to the spine but does not cover spinal injury caused by a disease.It aims to reduce death and disability by improving the quality of emergency and urgent care.

This guideline includes recommendations on:
  - initial triage and management by pre-hospital care staff
  - clinical assessment and management at the emergency department
  - acute stage imaging
  - communication with tertiary services
  - information and support needs of patients and their families and carers
  - documentation

Clinical Trials

Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

-31 days ago

The purpose of this study is to determine whether aFT218 is safe and effective for the treatment of excessive daytime sleepiness and cataplexy in subjects with ...

Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer

Sun 01 May 2016

The purpose of this phase 2 trial is to study the activity of pembrolizumab in combination with bevacizumab in patients with untreated brain metastases from melanoma or NSCLC to determine activity ...

Back to top