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Learning Zones

,Hyperammonaemia Knowledge Centre

Hyperammonaemia is a metabolic disturbance characterised by an excess of ammonia in the blood, and can have wide-ranging effects on metabolic, neurological and gastrointestinal systems.

The Hyperammonaemia Knowledge Centre has been developed to raise awareness of this rare yet potentially deadly condition. Using this resource, healthcare professionals are encouraged to recognise the signs and symptoms of hyperammonaemia and begin the correct treatment immediately.

Content in this resource is divided into the following sections:

  • Disease Awareness: epidemiology, pathophysiology, signs & symptoms, etc.
  • Carglumic Acid: information on drug characteristics, clinical efficacy, safety/tolerability and more
  • Video Channel: expert video presentations from Orphan Europe’s satellite symposium ‘Hyperammonaemia: a true medical emergency' at EAPS 2012
  • Resources: links to expert centres, European societies, treatment guidelines and more
  • E-learning: healthcare professionals can test their knowledge with clinically useful and current information through a series of case studies
 

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Clinical Case Studies

Pneumococcal Meningitis

Infection: Central Nervous System Infection

R. Andrew Seaton, MBChB, MD, DTM&H, FRCP (Edinburgh & Glasgow), Consultant in Infectious Diseases and General Medicine, Honorary Senior Lecturer, University of Glasgow, Brownlee Centre for Infectious Diseases and Tropical Medicine, Gartnavel General Hospital, Glasgow, UK

Case History
A 65-year-old lady was admitted to the emergency department having been found unconscious, febrile and incontinent of urine.

Brain Abscess

Infection: Central Nervous System Infection

Christine Peters, Specialist Registrar in Medical Microbiology, Southern General Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK

Case History
A normally fit and well 31-year-old man presented to the emergency department with a severe headache of nine days duration. He had a Glasgow Coma Scale (GCS) of 15, expressive dysphasia and a mild right facial weakness, but was apyrexial and normotensive.

Latest News

Medical Videos

An Overview of Brain Surgery and the Current Understanding of Brain Function
An Overview of Brain Surgery and the Current Understanding of Brain Function
Does chronic venous insufficiency play a role in MS pathogenesis? Commentary (CONy 2010)
Does chronic venous insufficiency play a role in MS pathogenesis? Commentary (CONy 2010)

Recent Drug Updates

Medical Journal Abstracts on Neurological Disorders

The Role of Melatonin in the Treatment of Primary Headache Disorders.

Fri 17 Jun 2016 -  The Role of Melatonin in the Treatment of Primary Headache Disorders.

Objective: To provide a summary of knowledge about the use of melatonin in the treatment of primary headache disorders. Background: Melatonin is secreted by the pineal gland; its production is ...

Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.

Fri 22 Apr 2016 -  Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.

Background: Substantial concerns have been raised about the neuropsychiatric safety of the smoking cessation medications varenicline and bupropion. Their efficacy relative to nicotine patch largely ...

Medical Images

PML from a brain biopsy specimen
PML from a brain biopsy specimen
T1-weighted transverse cranial MRI
T1-weighted transverse cranial MRI
Single large left posterior fossa lesion
Single large left posterior fossa lesion
Miliary TB
Miliary TB
MRIs performed in a 37-year-old HIV+ patient
 MRIs performed in a 37-year-old HIV+ patient
Ring-enhancing lesion (arrow) in the middle of moderate peri-lesional cerebral oedema
Ring-enhancing lesion (arrow) in the middle of moderate peri-lesional cerebral oedema
CT head with contrast, shows oedema, enhancement of tuberculoma increased
 CT head with contrast, shows oedema, enhancement of tuberculoma increased
CNS IRIS after ARV initiation
CNS IRIS after ARV initiation
Large cerebral tuberculoma on MRI
Large cerebral tuberculoma on MRI
Immunocytochemical staining
Immunocytochemical staining

Clinical Guidelines

Guidelines on Neuro-Urology

Mar 2016

The European Association of Urology (EAU) Neuro-Urology Guidelines aim to provide information for..

... clinical practitioners on the incidence, definitions, diagnosis, therapy, and follow-up of neuro-urological disorders. These Guidelines reflect the current opinion of experts in this specific pathology and represent a state-of-the-art reference for all clinicians, as of the publication date.

Spinal injury: assessment and initial management

Feb 2016

This guideline covers the assessment and early management of spinal column and spinal cord injury..

... in pre-hospital settings (including ambulance services), emergency departments and major trauma centres. It covers traumatic injuries to the spine but does not cover spinal injury caused by a disease.It aims to reduce death and disability by improving the quality of emergency and urgent care.

This guideline includes recommendations on:
  - initial triage and management by pre-hospital care staff
  - clinical assessment and management at the emergency department
  - acute stage imaging
  - communication with tertiary services
  - information and support needs of patients and their families and carers
  - documentation

Clinical Trials

Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

Fri 01 Jul 2016

The purpose of this study is to determine whether aFT218 is safe and effective for the treatment of excessive daytime sleepiness and cataplexy in subjects with ...

A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia (NAVIGATE-AD)

Wed 01 Jun 2016

The main purpose of this study is to evaluate the safety and the effect on brain tau of the study drug LY3202626 in participants with mild Alzheimer's disease (AD) ...

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