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Drug Details

Lemsip Max Day & Night Cold and Flu Relief Capsules

• Presentation
  Capsule, hard. Day capsule: Red/yellow hard gelatin capsules. Night capsule: Red/blue hard gelatin capsules.
• Description
  Lemsip Max Day & Night Cold & Flu Relief Capsules
• Indications
  

  Day Capsule:

  For the relief of symptoms associated with the common cold and influenza including relief of aches and pains, sore throat, headache, fatigue and drowsiness, nasal congestion and lowering of temperature.

  Night Capsule:

  For the relief of symptoms associated with colds and influenza including relief of aches and pains, sore throat, headache, lowering of temperature and the symptoms associated with nasal congestion to help allow sleep through relief of nasal congestion.

• Adult Dosage
  

  Adults and children 12 years and over:

  Two red and yellow capsules every 4-6 hours during the day to a maximum of 3 doses.

  Do not exceed 6 red and yellow capsules in any 24 hours.

  Two blue and red capsules to be taken at night.

   

  Do not exceed 8 capsules in total in any 24 hours.

  Swallow whole with water. Do not chew.

   

  Do not give to children under 12 years.

• Contra Indications
  

  Hypersensitivity to any of the other constituents.

  Phenylephrine hydrochloride: Severe coronary heart disease and cardiovascular disorders. Hypertension. Hyperthyroidism. Contraindicated in patients currently receiving or within two weeks of stopping therapy with monoamine oxidase inhibitors.

• Special Precautions
  

  Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease.

  Use with caution in patients with Raynaud's Phenomenon and diabetes mellitus.

  Caffeine: Should be given with care to patients with a history of peptic ulcer.

  Label and leaflet warning: Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.

  Do not exceed the stated dose. Do not take with any other paracetamol-containing products. If symptoms persist consult your doctor. Keep out of the reach and sight of children. If you are pregnant or are being prescribed medicine by your doctor, seek his advice before taking this product. Contains paracetamol (panel).

• Interactions
  

  The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by cholestyramine.

  The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.

  Phenylephrine may adversely interact with other sympathomimetics, vasodilators and beta-blockers. Drugs which induce hepatic microsomal enzymes, such as alcohol, barbiturates, monoamine oxidase inhibitors and tricyclic antidepressants, may increase the hepatotoxicity of paracetamol, particularly after overdosage. Contraindicated in patients currently receiving or within two weeks of stopping therapy with monoamine oxidase inhibitors because of a risk of hypertensive crisis.

  Caffeine undergoes extensive metabolism by hepatic microsomal cytochrome P450, factors known to alter the activity of this enzyme system may influence caffeine clearance. Thus, caffeine elimination is enhanced in cigarette smokers and inhibited by cimetidine, disulfiram and oral contraceptive steroids.

• Adverse Drug Reactions
  

  Adverse effects of paracetamol are rare, but hypersensitivity including skin rash may occur. There have been a few reports of blood dyscrasias including thrombocytopenia and agranulocytosis, but these were not necessarily causally related to paracetamol.

  Phenylephrine hydrochloride: High blood pressure with headache, vomiting and palpitations. Also rare reports of allergic reactions.

  The most commonly reported adverse events following dosing with caffeine are GI irritation and CNS stimulation. Adverse CNS effects include insomnia, restlessness, nervousness and mild delirium; adverse GI effects include nausea, vomiting and gastric irritation.