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Drug Details

Beechams All-In-One Tablets

• Presentation
  Tablets. White, film-coated tablets embossed with a 'B' on one side
• Description
  Each tablet contains paracetamol 250 mg, guaifenesin 100 mg and phenylephrine hydrochloride 5 mg Contains lactose
• Indications
  Short term symptomatic relief of colds, chills and influenza including chesty coughs.
• Adult Dosage
  

  Adults and children 12 years and over

  Two tablets. Repeat every four hours as necessary.

  Do not take more than 8 tablets in 24 hours.

  Not to be given to children under 12 years except on medical advice

• Elderly Dosage
  

  The normal adult dose may be taken

• Contra Indications
  

  Known hypersensitivity to any of the ingredients.

  Hepatic or severe renal impairment, hypertension, hyperthyroidism, diabetes, heart disease or those taking tricyclic antidepressants, monoamine oxidase inhibitors or beta-blocking drugs.

• Special Precautions
  

  Long term use of the product is not recommended.

  Concomitant use of other cold or decongestant products or other paracetamol-containing products should be avoided. If symptoms persist consult your doctor.

  Keep out of the reach and sight of children.

  Patients with rare hereditary problems of galactose intolerance, the Lapp lactose deficiency or glucose-galactose malabsoption should not take this medicine.

   

  Special label warnings

  Do not take with any other paracetamol-containing products. Do not take with other flu, cold or decongestant products.

  Immediate medical advice should be sought in the event of an overdose, even if you feel well.

   

  Special leaflet warnings

  Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.

• Interactions
  

  The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular use of paracetamol with increased risk of bleeding. The hepato-toxicity of paracetamol may be potentiated by excessive intake of alcohol. The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by colestyramine. Pharmacological interactions involving paracetamol with a number of other drugs have been reported. These are considered to be of unlikely clinical significance in acute use at the dosage regimen proposed.

  Hypertensive interactions occur between sympathomimetic amines such as phenylephrine and monoamine oxidase inhibitors. Phenylephrine may reduce the efficacy of beta-blocking drugs and antihypertensive drugs. Conditions where these drugs are used are contraindications for the product.

• Adverse Drug Reactions
  

  The active ingredients are usually well tolerated in normal use.

  Skin rashes and other allergies occur occasionally with paracetamol. There have been few reports of blood disorders including agranulocytosis and thrombocytopenia after regular or excessive ingestion of paracetamol, and of acute pancreatitis after ingestion of above normal dosage.

  Gastrointestinal discomfort has occasionally been reported with guaifenesin.

  Sympathomimetic amines may elevate blood pressure with headache, dizziness, vomiting, diarrhoea, insomnia and palpitations, though there have been few reports of these effects with normal doses of phenylephrine.