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Drug Details

Andrews Plus+

• Presentation
  Effervescent powder. A free-flowing creamy/white powder with a characteristic orange odour. Free from large aggregates and particulate contamination
• Description
  Each sachet contains; 1000 mg Paracetamol, Anhydrous citric acid 1185 mg, Sodium bicarbonate 808 mg, Potassium bicarbonate 715 mg, Anhydrous sodium carbonate 153 mg, Vitamin C (Ascorbic acid) 30 mg.
• Indications
  Recommended for the relief of headache with gastric upset, particularly associated with over-indulgence in food or drink or both.
• Adult Dosage
  

  For oral administration.

  Dissolve the contents of the sachet in a glass of water (150 – 200 ml) before taking.

  Adults, elderly and children aged 16 years and over:

  One sachet every 4 hours as required. Do not take more than 4 sachets in any 24 hours.

  Not to be given to children under 16 years of age.

  The elderly may take the normal adult dose.

• Contra Indications
  

  Known hypersensitivity to any of the ingredients. Hepatic or severe renal impairment. Patients on sodium-restricted diets.

• Special Precautions
  

  Concomitant use of other paracetamol-containing medicines should be avoided. Consult your doctor if you are taking warfarin.

  “Sachet warnings: Immediate medical advice should be sought in the event of an overdose, even if you feel well. Do not take with other paracetamol containing products”.

  “Carton label: Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage”.

• Interactions
  

  The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular use of paracetamol with increased risk of bleeding. Occasional doses have no significant effect. The hepatototoxicity of paracetamol may be potentiated by excessive intake of alcohol. The speed of absorption of paracetamol may be increased by metaclopramide or domperidone and absorption reduced by cholestyramine. These interactions are considered to be of unlikely clinical significance in acute use at the dosage regimen proposed.

  The acid neutralising capacity of the product may alter the absorption profile of pH specific drugs given concomitantly.

• Adverse Drug Reactions
  

  Adverse effects of paracetamol are rare but hypersensitivity including skin rash may occur. There have been reports of blood dyscrasias including thrombocytopenia and agranulocytosis, but these were not necessarily causality related to paracetamol.