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Drug Details

ONCOVIN

• Drug Class Description
  Vinca alkaloids (cytotoxics).
• Generic Name
  Vincristine
• Presentation
  Injection, vincristine sulphate 1 mg /mL.
• Description
  Solution in vial (1mg/1mL or 2mg/ 2mL).
• Indications
  

  For intravenous use. Information available suggests Oncovin may be useful either alone or in combination with other oncolytic drugs for the treatment of leukaemias; malignant lymphomas; multiple myeloma; solid tumours; paediatric solid tumours; idiopathic thrombocytopenic purpura.

• Adult Dosage
  

  For intravenous use only; fatal if given intrathecally.

  Should be administered only by individuals experienced in vincristine administration. Recommended dosage is 1.4 - 1.5mg/m 2 intravenously at weekly intervals; maximum weekly dose, 2g.

• Child Dosage
  

  For intravenous use only; For intravenous use only; intrathecal administration usually results in death. Usual dose, 2mg/m2 once a week. For children weighing 10kg or less, starting dose should be 0.5mg/kg once a week.

• Contra Indications
  Intrathecal administration. Patients with demyelinating form of Charcot-Marie-Tooth syndrome should not be given vincristine.
• Special Precautions
  

  Pregnancy and lactation.

• Interactions
  Mitomycin-C, phenytoin, itraconazole and other drugs that inhibit cytochrome P450 CYP 3A enzymes, L-asparaginase.