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Drug Details

YUTOPAR

• Drug Class Description
  b-agonists (beta-agonists, beta- adrenoceptor stimulants).
• Generic Name
  Ritodrine
• Presentation
  Yutopar Tablets: Ritodrine hydrochloride 10 mg . Yutopar: Ritodrine hydrochloride 10 mg /mL.
• Description
  Yutopar Tablets: yellow, scored tablet marked YUTOPAR. Yutopar: ampoule.
• Indications
  

  Yutopar Tablets: Follow-on to Yutopar

  Tablets: Follow-on to parenteral therapy to maintain uterine quiescence.

  Yutopar: Uncomplicated preterm labour between 24 - 33 weeks gestation. To delay delivery to enable glucocorticosteroids or other measures to be used.

• Adult Dosage
  

  Yutopar Tablets: 1 approximately 30 minutes before termination of intravenous therapy. Maintenance: 1 two hourly for 24 hours, then 1 or 2 four to six hourly.

  Yutopar: Initially 50 microgram/ minute intravenously in 5% dextrose solution, increase gradually until control. Usual range, 150 - 350 microgram/ minute. Continue infusion for 12 - 48 hours after contractions have stopped. Use a syringe pump to reduce fluid overload.

• Child Dosage
  Not applicable.
• Contra Indications
  Antepartum haemorrhage, eclampsia, pre-eclampsia, cord compression, foetal death, chorioamnionitis, maternal cardiac disease.
• Special Precautions
  Avoid fluid overload; keep intravenous fluids to minimum and monitor maternal hydration. Multiple pregnancy, suspected cardiovascular disease, maternal infection, hyperthyroidism, hypertension, diabetes. Monitor maternal and foetal heart rate.
• Interactions
  MAOIs, tricyclic antidepressants, corticosteroids, sympathomimetics, anaesthetics, K+-depleting diuretics, b- blockers.
• Adverse Drug Reactions
  Maternal pulmonary oedema (withdraw drug immediately and institute diuretic therapy). Tachycardia, flushing, sweating, nausea, chest pain, arrhythmia, vomiting, rise in blood sugar, tremor, leucopenia and/or agranulocytosis, impaired liver function, raised liver transaminases, enlarged salivary glands, increased amylase