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Drug Details

ELLESTE DUET

• Drug Class Description
  Oestrogens / progestogens.
• Generic Name
  Estradiol [oestradiol]
• Presentation
  Elleste Duet 1 mg : Estradiol 1 mg . Elleste Duet 2 mg : Estradiol 2 mg .
• Description
  Elleste Duet 1 mg: (16 white f-c tablets marked 01); estradiol 1 mg, norethisterone acetate 1 mg (12 green f-c tablets marked P1). Elleste Duet 2 mg: (16 orange f-c tablets marked 02); estradiol 2 mg, norethisterone acetate 1 mg (12 grey f-c tablets marked P2).
• Indications
  Elleste Duet 1 mg: Menopausal symptoms. Elleste Duet 2 mg: Menopausal symptoms, prevention of postmenopausal osteoporosis.
• Adult Dosage
  

  Elleste Duet 1 mg: 1 daily starting with white tablet on 1st day of cycle or at any time if not menstruating regularly, then 1 green tablet for next 12 days. Start next cycle without a break.

  Elleste Duet 2 mg: 1 daily starting with orange tablet on 1st day of cycle or at any time if not menstruating regularly, then 1 grey tablet for next 12 days. Start next cycle without a break.

• Child Dosage
  Not applicable.
• Contra Indications
  

  Cancer of breast, genital tract or other oestrogen-dependent carcinoma, undiagnosed vaginal bleeding or endometriosis. Active thrombophlebitis or thromboembolic disorders. Severe cardiac, hepatic or renal disease. Dubin-Johnson or Rotor syndromes. Pregnancy, lactation.

• Special Precautions
  

  History or increased risk of thromboembolic disorders. Mild chronic liver disease; monitor liver function every 8 to 12 with cholelithiasis, otosclerosis, migraine, multiple sclerosis, epilepsy, diabetes, hypertension, porphyria, uterine fibroids, tetany. Examine blood pressure, pelvic organs and breasts (particularly those with fibrocystic disease of the breast or a family history of breast cancer) before and regularly during treatment. If breakthrough bleeding is persistent, perform endometrial assessment, which may include biopsy.

• Interactions
  Liver enzyme inducing drugs.
• Adverse Drug Reactions
  

  GI upset, nausea, vomiting, weight gain, breast tenderness and enlargement, breakthrough bleeding, headache, dizziness, impaired liver function, cholestatic jaundice, epistaxis, migraine, thromboembolic disorders, exacerbation of varicose veins, increased blood pressure, transient erythema, generalised pruritus.

  REASONS FOR IMMEDIATE DISCONTINUATION OF TREATMENT: Occurence of migraine-type headaches for the first time, frequent severe headaches, acute visual disturbances, signs of thrombophlebitis or thromboembolism, or any other possible prodromal symptoms of vascular occlusion. Rise in blood pressure. Jaundice. Pregnancy. Discontinue six weeks before major elective surgery and during immobilisation entailing risk of thrombosis.