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Drug Details

Deca-Durabolin 50mg/ml

• Drug Class Description
  Anabolic steroids.
• Generic Name
  Nandrolone decanoate - osteoporosis
• Presentation
  Solution for injection.
• Description
  Each ml of Deca Durabolin contains 50mg nandrolone decanoate.
• Indications
  For use in osteoporosis in post-menopausal women. Established osteoporosis should have been diagnosed by the following parameters: i) crush or wedge fractures of the vertebrae ii) other osteoporotic fractures iii) established reduction in bone mineral content as measured by accepted BMC measurements.
• Adult Dosage
  

  Dosage

  Post-menopausal women

  50 mg every three weeks.

  The duration of treatment depends on the clinical response and the possible occurrence of side-effects.

  We would recommend that the effectiveness of therapy be monitored with the appropriate methods for osteoporosis on a 6-12 monthly basis.

  Children

  There are no recommendations for use in children.

  Administration

  Deep intramuscular injection

• Child Dosage
  Not applicable.
• Contra Indications
  

  Pregnancy

  Breast-feeding

  Porphyria

  Allergies to any of the components

  Known or suspected carcinoma of prostate or mammary carcinoma in the male

• Special Precautions
  

  If signs of virilisation develop, discontinuation of the treatment should be considered.

  Patients, especially the elderly, with the following conditions should be monitored:

  • latent or overt cardiac failure, renal dysfunction, hypertension, epilepsy or migraine (or a history of these conditions), since anabolic steroids may occasionally induce sodium and water retention;

  • incomplete statural growth, since anabolic steroids in high dosages may accelerate epiphyseal closure;

  • skeletal metastases, since anabolic steroids may induce hypercalcaemia and hypercalciuria in these patients;

  • liver dysfunction - caution should be used in patients with severe hepatic impairment and Deca Durabolin 50mg/ml should only be used if the benefits outweigh the risks.

  • diabetes mellitus

  Deca Durabolin 50mg/ml contains Arachis oil (peanut oil) and should not be taken / applied by patients known to be allergic to peanut. As there is a possible relationship between allergy to peanut and allergy to Soya, patients with Soya allergy should also avoid Deca Durabolin 50mg/ml.

• Interactions
  

  Anabolic steroids may improve glucose tolerance and decrease the need for insulin or other anti-diabetic drugs in diabetics.

  Anabolic steroids have been reported to increase the activity of oral anticoagulants. Patients receiving oral anticoagulants require close monitoring, especially at the beginning or end of androgen therapy. Increased monitoring of the prothrombin time, and INR determinations, are recommended.

• Adverse Drug Reactions
  

  Deca-Durabolin at the recommended dosages is unlikely to produce virilising effects. High dosages, prolonged treatment and/or too frequent administration may cause:

  • Virilisation which appears in sensitive women as hoarseness, acne, hirsutism and increase of libido; in prepubertal boys as an increased frequency of erections and phallic enlargement, and in girls as an increase of pubic hair and clitoral hypertrophy. Hoarseness may be the first symptom of vocal change which may end in long-lasting, sometimes irreversible deepening of the voice;

  • Amenorrhoea and inhibition of spermatogenesis;

  • Premature epiphyseal closure;

  • Sodium and water retention.

  Abnormal liver function tests have been reported in patients treated with (high doses) of Deca-Durabolin.

  Liver tumours have been reported occasionally on prolonged treatment with orally active C17-alpha alkylated anabolic steroids. A relationship between liver tumours and non-C17-alkylated injectable steroids, such as nandrolone esters, appears to be highly unlikely, but cannot be absolutely excluded.