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Drug Details

Danazol (endometriosis)

• Drug Class Description
  Gonadotrophin release inhibitors.
• Generic Name
  Generic
• Presentation
  Capsules, danazol 100 mg , 200 mg . Available from Cox, Generics UK, Hillcross, Norton (200mg only), Sterwin.
• Description
  Capsules.
• Indications
  Endometriosis. Pre-operative preparation prior to hysteroscopic endometrial ablation.
• Adult Dosage
  

  Start on 1st day of menstruation and continue without interruption. Endometriosis, 200 - 800 mg daily for 6 - 9 months. Prior to ablation, 400 - 800 mg daily for 3 - 6 weeks.

• Child Dosage
  Not recommended.
• Elderly Dosage
  Not recommended.
• Contra Indications
  

  Pregnancy; use barrier contraception, withdraw therapy if patient conceives. Lactation, porphyria, severe hepatic, cardiac or renal dysfunction, thromboembolic disease, androgen thromboembolic disease, androgen dependent tumour, undiagnosed abnormal vaginal bleeding.

• Special Precautions
  

  Epilepsy, migraine, hepatic or renal disease, hypertension or other cardiovascular disease, history of thromboembolic disease, lipoprotein disorders, states exacerbated by fluid retention, polycythaemia, diabetes, known or suspected malignancy, androgenic reactions to previous gonadal steroid therapy. Monitor patient, hepatic function, haematology; withdraw if androgenic reactions, symptoms of raised intracranial pressure, liver dysfunction or thrombosis occur.

• Interactions
  Anticonvulsants, hypoglycaemics, anticoagulants, antihypertensives, cyclosporin, tacrolimus, steroids, migraine therapy, alcohol, alfacalcidol.
• Adverse Drug Reactions
  

  Nausea, dizziness, rash, backache, flushing, muscle spasm, androgenic effects, menstrual disturbances, fluid retention, headache, emotional lability, cholestatic jaundice, benign intracranial hypertension, cardiovascular reactions, haematological and thyroid effects, pancreatitis.