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Drug Details

HIBICET Hospital Concentrate

• Drug Class Description
  Disinfectants.
• Generic Name
  Chlorhexidine, cetrimide
• Presentation
  Liquid.
• Description
  Chlorhexidine gluconate 1.5% w/v (incorporated as Chlorhexidine Gluconate Solution Ph.Eur. 7.5% v/v); cetrimide 15% w/v (incorporated as strong cetrimide solution Ph.Eur.)
• Indications
  Hibicet Hospital Concentrate is an antimicrobial preparation with cleansing properties for general antiseptic purposes
• Adult Dosage
  

  For external use only. Dilute as follows:

  Method of Preparation	Dilution	Use
  10ml made up to 1 litre with water	1 in 100 (1%) aqueous	Cleansing/antiseptic treatment of wounds and burns * Swabbing in obstetrics, gynaecology and urology. Cleansing/disinfectant soak for used metal instruments. Clean instrument disinfection where no means of sterilisation is available (30 minutes immersion)** Cleansing/disinfection of equipment, furniture and fittings in the vicinity of the patient. Storage of clinical thermometers and sterile instruments.
  35ml made up to 1 litre with water	1 in 30 (approx) aqueous	Cleansing/antiseptic treatment of wounds and burns where greater cleansing/antisepsis is required* Cleansing/disinfectant soak for soiled instruments.
  35ml with 200ml water made up to 1 litre with 95% alcohol	1 in 30 (approx) in 70% alcohol	Rapid skin antisepsis before operation and other invasive procedures. Disinfection of clean instruments and equipment (2 minutes immersion)** Disinfection of clinical thermometers.

  * sterilise the dilution by autoclaving at 115º– 116ºC for 30 minutes or 121º– 123ºC for 15 minutes

  ** endoscopes should not be placed in solution of Hibicet

  Children and elderly patients: there are no special dosage recommendations for either elderly patients or children. The normal adult dose is appropriate unless otherwise recommended by the physician.

• Contra Indications
  

  Hibicet preparations are contraindicated for patients who have previously shown a hypersensitivity reaction to either chlorhexidine or cetrimide. However, such reactions are extremely rare.

• Special Precautions
  

  For external use only. Dilute before use. Avoid contact with the brain, meninges and ears. Not for injection. Do not use in body cavities or as an enema.

  The concentrated solution is irritant to eyes and mucous membranes. Keep all solutions out of the eyes. If solutions do come into contact with eyes, wash out promptly and thoroughly with water. If concentrated cetrimide solutions come into contact with the skin, rinse promptly and thoroughly with water.

  Prolonged skin contact with alcoholic solutions should be avoided. Allow to dry before proceeding.

  Solutions applied to wounds, burns or broken skin should be sterilised according to BP recommendations.

  Syringes and needles which have been immersed in Hibicet solutions should be thoroughly rinsed in sterile water or saline before use.

  Hibicet solutions may affect glass cement and therefore are not suitable for the disinfection of endoscopes.

• Adverse Drug Reactions
  

  Irritative skin reactions can occasionally occur and rare hypersensitivity to cetrimide preparations, usually developing after repeated application, has been reported.

  There have been rare reports of severe burn-like reactions to concentrate cetrimide solutions. Should such a reaction occur treat as a chemical burn.

  Generalised allergic reactions to chlorhexidine have also been reported but are extremely rare.

  In all these cases, stop application of the product.