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Drug Details

PABRINEX

• Drug Class Description
  Vitamins (vitamin C, B vitamins).
• Generic Name
  Vitamins B & C
• Presentation
  Injection for intramuscular use: two (5ml, 2ml) amber glass ampoules containing sterile aqueous solutions which are to be mixed prior to administration.
• Description
  Pabrinex Intramuscular High Potency
• Indications
  Rapid therapy of severe depletion or malabsorption of the water soluble vitamins B and C, particularly in alcoholism, after acute infections, post-operatively and in psychiatric states.
• Adult Dosage
  

  Pabrinex is also available as an Intravenous High Potency Injection.

  The contents of one ampoule number 1 and one ampoule number 2 of Pabrinex Intramuscular High Potency (total 7ml) are drawn up into a syringe to mix them just before use, then injected slowly high into the gluteal muscle, 5cm below the iliac crest.

  Adults: The contents of one pair of ampoules (7ml) twice daily for up to 7 days.

  Children: Pabrinex Intramuscular High Potency is rarely indicated for administration to children, however suitable doses are as follows:

  Under 6 years	one quarter of the adult dose
  6-10 years	one third of the adult dose
  10-12 years	one half to two thirds of the adult dose
  14 years and over	as for the adult dose

• Contra Indications
  

  Known hypersensitivity to any of the active constituents.

• Special Precautions
  

  Repeated injections of preparations containing high concentrations of vitamin B₁ (thiamine) may give rise to anaphylactic shock. Mild allergic reactions such as sneezing or mild asthma are warning signs that further injections may give rise to anaphylactic shock. Facilities for treating anaphylactic reactions should be available whenever Pabrinex Intramuscular High Potency is administered.

  Not for intravenous use.

• Interactions
  

  The content of pyridoxine may interfere with the effects of concurrent levodopa therapy.

• Adverse Drug Reactions
  

  Occasionally, hypotension and mild paraesthesia from continued high doses of thiamine; occasionally mild ache at local site of injection.