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Drug Details

FANSIDAR

• Drug Class Description
  Sulphonamides / diaminopyrimidines (antimalarials).
• Generic Name
  Sulfadoxine, pyrimethamine
• Presentation
  Tablets, sulfadoxine 500mg, pyrimethamine 25mg.
• Description
  White quarter-scored tablets marked ROCHE with hexagon.
• Indications
  Indicated for the treatment of Plasmodium falciparum malaria and in restricted circumstances can be used for the prophylaxis  can be used for the prophylaxis of Plasmodium falciparum malaria.
• Adult Dosage
  Treatment, over 14 years, 2 - 3 tablets as a single dose. Prophylaxis, over 14 years, 1 weekly. Refer to Summary of Product Characteristics.
• Child Dosage
  Treatment, given as a single dose: under 2 years (5-10kg), half a tablet; 2 - 5 years (>10- 20kg), one tablet; 5 - 10 years (>20-30kg), one and a half tablets; 10 - 14 years (>30-45kg) , two tablets. Prophylaxis, given once every seven days: under 2 years (5- 10kg), quarter of a tablet; 2 - 10 years (>10-30kg), half a tablet; 10 - 14 years (>30-45kg), three quarters of a tablet. Refer to Summary of Product Characteristics.
• Contra Indications
  Sulphonamide sensitivity. Severe liver or kidney dysfunction. Blood dyscrasias. Neonates, pregnancy, lactation.
• Special Precautions
  Perform regular blood counts during long-term prophylaxis. Avoid excess sun.
• Interactions
  Folate inhibitors.
• Adverse Drug Reactions
  

  Skin rash, pharyngitis or pruritus (discontinue immediately). GI distress, blood dyscrasias. Rarely erythema multiforme, Stevens-Johnson syndrome, Lyell's syndrome.