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Drug Details

Calceos

• Drug Class Description
  Calcium supplements / vitamin D3.
• Generic Name
  calcium carbonate, colecalciferol
• Presentation
  Chewable tablets, for oral administration.
• Description
  Calcium Carbonate 1250mg (i.e. 500mg or 12.5mmol of elemental calcium). Colecalciferol (INN) (Vitamin D3) 10?g (corresponding to 400IU of Vitamin D3).
• Indications
  

  Vitamin D and calcium deficiency correction in the elderly. Vitamin and calcium supplement as an adjunct to specific therapy for osteoporosis.

• Adult Dosage
  

  Oral use. For adults only. One tablet, twice per day. Chew the tablets and drink a glass of water.

• Child Dosage
  Not recommended.
• Contra Indications
  

  Hypersensitivity to one of the constituents. Hypercalcaemia as a result of hyperparathyroidism (primary or secondary), hypercalciuria, calcium lithiasis, tissue calcification (nephrocalcinosis). Vitamin D overdose. Myeloma and bone metastases. Renal insufficiency (creatinine clearance less than 20ml/min). Calceos tablets are also contra-indicated in patients where prolonged immobilisation is accompanied by hypercalcaemia and/or hypercalciuria. In these cases, treatments should only be resumed when the patient becomes mobile.

  This product contains partially hydrogenated soybean oil. Patients should not take this medicinal product if they are allergic to peanut or soya.

• Special Precautions
  

  Calculate the total Vitamin D intake in case of treatment with another drug containing this vitamin.

  The following may be important in patient monitoring: plasma calcium and urinary calcium determinations.

  Precautions:

  Plasma and urinary calcium levels should be monitored regularly.

  In the elderly, renal function must be monitored regularly.

  In patients with renal failure, dosage has to be adapted according to the creatinine clearance.

  In case of long term treatment, the urinary calcium excretion must be monitored and treatment must be reduced or momentarily suspended if urinary calcium exceeds 7.5 to 9mmol/24h (300 to 360mg/24h).

  This product contains sorbitol (E420) and sucrose. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.

  The sucrose in this product may be harmful to teeth if taken chronically, e.g. for two weeks or more.

• Interactions
  

  In case of treatment with digitalis glycosides: risk of cardiac arrhythmias. Clinical surveillance is required and possibly electrocardiographic and plasma calcium monitoring are recommended.

  Associations to be taken into account in the case of treatment with thiazide diuretics: risk of hypercalcaemia by decreasing urinary calcium excretion.

  Calcium may impair the absorption of tetracyclines, etidronate, fluoride and iron. At least 3 hours should intervene between taking Calceos and these agents.

  Possible interaction with food, for example foods containing oxalic acid (e.g. spinach, rhubarb, sorrel, cocoa, tea), phosphate (e.g. ham, sausages, cheese spread) or phytic acid (e.g. pulses, whole cereals, chocolate). These types of foods may reduce the absorption of calcium. It is therefore recommended that meals containing these foods be taken some time (e.g. two hours) before or after ingestion of the product.

• Adverse Drug Reactions
  

  - Hypercalciuria in cases of prolonged treatment at high doses, exceptionally hypercalcaemia.

  - Hypophosphataemia

  - Nausea

  - Mild gastro-intestinal disturbances such as constipation can occur but are infrequent

  - This product contains sucrose. May be harmful to teeth if taken chronically, e.g. for two weeks or more.