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Drug Details

NEGRAM (general infections)

• Drug Class Description
  4-quinolones (quinolones).
• Generic Name
  Nalidixic acid - GI infections
• Presentation
  Negram Tablets: Nalidixic acid 500 mg Negram Suspension: Nalidixic acid 300 mg/5 mL .
• Description
  Negram Tablets: light brown tablets marked NEGRAM. Negram Suspension: suspension.
• Indications
  Treatment of acute or chronic infections, especially those of the urinary tract caused by Gram- negative organisms, other than Pseudomonas species, sensitive to nalidixic acid. It may also be used for the treatment of selected cases of gastrointestinal Gram-negative infections sensitive to nalidixic acid (though relapse rate and treatment failure in gastrointestinal infection may be more common).
• Adult Dosage
  500 mg - 1 g four times daily 1 hour before meals.
• Child Dosage
  Under 3 months, not recommended; 3 months - 12 years, up to 50 mg/ kg daily in divided doses.
• Contra Indications
  History of convulsive disorders. Porphyria. Lactation.
• Special Precautions
  Liver disease, severe kidney dysfunction. Avoid unnecessary exposure to sunlight. Pregnancy.
• Interactions
  Anticoagulants, probenecid, melphalan, antibacterials, cyclosporin.
• Adverse Drug Reactions
  GI effects, visual disturbances. Skin rashes, photosensitivity, seizures, CNS effects, haemolytic anaemia, thrombocytopenia, leucopenia.