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Drug Details

NEBCIN

• Drug Class Description
  Aminoglycosides.
• Generic Name
  Tobramycin
• Presentation
  Injection, tobramycin (as sulphate) 20, 40 and 80 mg .
• Description
  Solution in vials.
• Indications
  

  Treatment of the following infections caused by susceptible micro-organisms: central nervous system infections (including meningitis, septicaemia and neonatal sepsis); gastrointestinal infections (including peritonitis, complicated and recurrent urinary tract infections); lower respiratory tract infections (including pneumonia, bronchopneumonia and acute bronchitis); skin, bone and soft tissue infections (including burns).

  Tobramycin is usually active against most strains of the following organisms: Pseudomonas aeruginosa; Proteus species (indole positive and indole negative), including Pr. mirabilis, Pr. rettgeri and Pr. vulgaris; Morganella morganii; vulgaris; Morganella morganii; Escherichia coli; Klebsiella- Enterobacter-Serratia species; Citrobacter species; Providencia species; Staphylococci including Staphylococcus aureus (coagulase-positive and coagulase-negative).

• Adult Dosage
  3 - 5 mg/kg daily in three or four divided doses by intramuscular injection or intravenous injection or infusion.
• Child Dosage
  Neonates, up to 4 mg/kg daily in two equal doses; others, 6 - 7.5 mg/kg daily in three or four divided doses.
• Contra Indications
  Pregnancy, lactation.
• Special Precautions
  Renal impairment; control blood levels and dosage.
• Interactions
  Other aminoglycosides, loop diuretics, neuromuscular blocking agents.
• Adverse Drug Reactions
  Anaphylaxis, ototoxicity, nephrotoxicity. Raised liver enzymes.